Systematic name M47990
Brief description Matrisome proteins found differentially expressed in secondary colorectal liver metastatases in comparison to normal colon and normal liver.
Full description or abstract In order to identify candidate biomarkers, we sought to define ECM signatures of metastatic colorectal cancers and their metastases to the liver. We obtained patient-matched metastatic colorectal cancer samples (primary tumor and paired metastases to liver) and normal colonic tissue from three patients from Massachusetts General Hospital s tissue bank. We also obtained normal liver tissue from healthy donors. We have used enrichment of ECM from human patient samples and proteomics to define the ECM composition of primary colon carcinomas and their metastases to liver in comparison with normal colon and liver samples. We defined, for each tissue or tumor type, its matrisome as the ensemble of proteins detected in at least two of the three patients studied. Based on these changes, we derived ECM protein signatures of primary colon carcinoma and primary colon tumor metastasis to liver. Comparisons of these signatures with available clinical gene expression array data show that subsets of these signatures correlate well with tumor progression and metastasis. Importantly, we identified subsets of tumor-specific proteins either characteristic of the colon tumor matrisome or characteristic of the metastasis matrisome. This gene set lists the matrisome proteins detected either exclusively or in significantly higher abundance in colorectal liver metastases compared to normal colon and liver.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 25037231   Authors: Naba A,Clauser KR,Whittaker CA,Carr SA,Tanabe KK,Hynes RO
Exact source 12885_2014_4731_MOESM2_ESM.xlsx, Figure 2E. Venn diagram shows comparisons among the metastatic colon cancer matrisomes (primary colon tumor and associated metastases to liver) and control tissue matrisomes (normal colon and normal liver)
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Source species Homo sapiens
Contributed by Alexandra Naba (University of Illinois Chicago)
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