Systematic name M41012
Brief description Genes positively correlated with HAI response in peripheral blood mononuclear cell in children (14-27m) (MF59-adjuvanted and non-adjuvanted) after exposure to Fluad/Imuvac , time point 1D. Comment: Genes in BTM M75
Full description or abstract The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59-adjuvanted TIV (ATIV) in 90 14- to 24-mo-old healthy children. MF59 enhanced the magnitude and kinetics of serum antibody titers following vaccination, and induced a greater frequency of vaccine specific, multicytokine-producing CD4(+) T cells. Compared with transcriptional responses to TIV vaccination previously reported in adults, responses to TIV in infants were markedly attenuated, limited to genes regulating antiviral and antigen presentation pathways, and observed only in a subset of vaccinees. In contrast, transcriptional responses to ATIV boost were more homogenous and robust. Interestingly, a day 1 gene signature characteristic of the innate response (antiviral IFN genes, dendritic cell, and monocyte responses) correlated with hemagglutination at day 28. These findings demonstrate that MF59 enhances the magnitude, kinetics, and consistency of the innate and adaptive response to vaccination with the seasonal influenza vaccine during early childhood, and identify potential molecular correlates of antibody responses.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 26755593   Authors: Nakaya HI,Clutterbuck E,Kazmin D,Wang L,Cortese M,Bosinger SE,Patel NB,Zak DE,Aderem A,Dong T,Del Giudice G,Rappuoli R,Cerundolo V,Pollard AJ,Pulendran B,Siegrist CA
Exact source Fig S7b
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Organism Homo sapiens
Source platform HUMAN_GENE_SYMBOL
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