Human Gene Set: NFE2L2.V2


Standard name NFE2L2.V2
Systematic name M2870
Brief description Genes down-regulated in MEF cells (embryonic fibroblasts) after knockout of NFE2L2 [GeneID=4780] gene.
Full description or abstract The transcription factor NRF2 (NFE2L2), induces a cytoprotective response to oxidative stresses and its mutations confer constitutive activation in cancer. We generated a gene set representing activation of NFE2L2, as represented by genes downregulated by NFE2L2 knockout using the data from Malhotra et al. D, et al. Nucleic Acids Res. 2010;38:5718-5734.
Collection C6: Oncogenic Signature
Source publication Pubmed 27088724   Authors: Kim JW,Botvinnik OB,Abudayyeh O,Birger C,Rosenbluh J,Shrestha Y,Abazeed ME,Hammerman PS,DiCara D,Konieczkowski DJ,Johannessen CM,Liberzon A,Alizad-Rahvar AR,Alexe G,Aguirre A,Ghandi M,Greulich H,Vazquez F,Weir BA,Van Allen EM,Tsherniak A,Shao DD,Zack TI,Noble M,Getz G,Beroukhim R,Garraway LA,Ardakani M,Romualdi C,Sales G,Barbie DA,Boehm JS,Hahn WC,Mesirov JP,Tamayo P
Exact source Knockout of NERF2 vs control; down-regulated genes
Related gene sets (show 154 gene sets from the same authors)
External links  
Filtered by similarity ?
Organism Mus musculus
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 469 genes
Gene families ? Categorize these 469 genes by gene family
Show members (show 481 members mapped to 469 genes)
Version history 7.0: Complete metadata correction

See MSigDB license terms here. Please note that certain gene sets have special access terms.