Human Gene Set: NFE2L2.V2

Standard name NFE2L2.V2
Systematic name M2870
Brief description Genes down-regulated in MEF cells (embryonic fibroblasts) after knockout of NFE2L2 [GeneID=4780] gene.
Full description or abstract The transcription factor NRF2 (NFE2L2), induces a cytoprotective response to oxidative stresses and its mutations confer constitutive activation in cancer. We generated a gene set representing activation of NFE2L2, as represented by genes downregulated by NFE2L2 knockout using the data from Malhotra et al. D, et al. Nucleic Acids Res. 2010;38:5718-5734.
Collection C6: Oncogenic Signature
Source publication Pubmed 27088724   Authors: Kim JW,Botvinnik OB,Abudayyeh O,Birger C,Rosenbluh J,Shrestha Y,Abazeed ME,Hammerman PS,DiCara D,Konieczkowski DJ,Johannessen CM,Liberzon A,Alizad-Rahvar AR,Alexe G,Aguirre A,Ghandi M,Greulich H,Vazquez F,Weir BA,Van Allen EM,Tsherniak A,Shao DD,Zack TI,Noble M,Getz G,Beroukhim R,Garraway LA,Ardakani M,Romualdi C,Sales G,Barbie DA,Boehm JS,Hahn WC,Mesirov JP,Tamayo P
Exact source Knockout of NERF2 vs control; down-regulated genes
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Source species Mus musculus
Contributed by Pablo Tamayo (Broad Institute)
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NCI-60 cell lines (National Cancer Institute)
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Version history 7.0: Complete metadata correction

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