Human Gene Set: OKUMURA_INFLAMMATORY_RESPONSE_LPS


Standard name OKUMURA_INFLAMMATORY_RESPONSE_LPS
Systematic name M1911
Brief description Genes up-regulated in mast cells (MC) after stimulation with a bacterial lipopolysaccharide (LPS).
Full description or abstract Rodent mast cells (MCs) are reported to play a pivotal role in both innate and adaptive immunity. However, there is so far no evidence that human MCs are involved in innate immunity. We found that a functional Toll-like receptor 4 (TLR4) was expressed on human MCs when it was up-regulated by interferon gamma (IFN-gamma). To systematically explore how human MCs modulate the immune system following TLR4-mediated activation and FcepsilonRI aggregation, we used high-density oligonucleotide probe arrays (GeneChip) to compare the lipopolysaccharide (LPS)-induced gene expression profile with the IgE/anti-IgE-mediated profile in MCs. Both a shared core response, and LPS- or anti-IgE-specific programs of gene expression were observed in MCs. Furthermore, MCs exhibited an antiviral response gene program in response to IFN-gamma, and LPS sustained that expression. Compared with the LPS-stimulated gene expression profile of human peripheral blood mononuclear cells, LPS-stimulated MCs specifically induced a subset of genes that included a Th2 cytokine and chemokines that recruit Th2 cells and eosinophils. These results reveal that human MCs express tailored pathogen- and antigen-specific immune responses and that human MCs may play important roles in innate and adaptive immunity.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12855579   Authors: Okumura S,Kashiwakura J,Tomita H,Matsumoto K,Nakajima T,Saito H,Okayama Y
Exact source Table 3-IS
Related gene sets (show 12 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Kate Stafford (MSigDB Team)
Source platform or
identifier namespace		 AFFY_HG_U133
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 182 genes
Gene families ? Categorize these 182 genes by gene family
Show members (show 218 source identifiers mapped to 182 genes)
Version history 3.0: Renamed from OKUMURA_MC_LPS

See MSigDB license terms here. Please note that certain gene sets have special access terms.