Standard name |
OVSYANNIKOVA_PBMC_FLUARIX_AGE_55_64YO_RESPONDERS_VS_NONRESPONDERS_28DY_UP |
Systematic name |
M40906 |
Brief description |
Genes up-regulated in peripheral blood mononuclear cell responders vs nonresponders in adults (55-64) after exposure to Fluarix , time point 28D. Comment: Gene expression related to HAI response |
Full description or abstract |
To assess gene signatures related to humoral response among healthy older subjects following seasonal influenza vaccination, we studied 94 healthy adults (50-74 years old) who received one documented dose of licensed trivalent influenza vaccine containing the A/California/7/2009 (H1N1)-like virus strain. Influenza-specific antibody (HAI) titer in serum samples and next-generation sequencing on PBMCs were performed using blood samples collected prior to (Day 0) and at two timepoints after (Days 3 and 28) vaccination. We identified a number of uncharacterized genes (ZNF300, NUP1333, KLK1 and others) and confirmed previous studies demonstrating specific genes/genesets that are important mediators of host immune responses and that displayed associations with antibody response to influenza A/H1N1 vaccine. These included interferon-regulatory transcription factors (IRF1/IRF2/IRF6/IRF7/IRF9), chemokine/chemokine receptors (CCR5/CCR9/CCL5), cytokine/cytokine receptors (IFNG/IL10RA/TNFRSF1A), protein kinases (MAP2K4/MAPK3), growth factor receptor (TGFBR1). The identification of gene signatures associated with antibody response represents an early stage in the science for which further research is needed. Such research may assist in the design of better vaccines to facilitate improved defenses against new influenza virus strains, as well as better understanding the genetic drivers of immune responses. |
Collection |
C7: Immunologic Signature VAX: HIPC Vaccine Response |
Source publication |
Pubmed 27441275 Authors: Ovsyannikova IG,Oberg AL,Kennedy RB,Zimmermann MT,Haralambieva IH,Goergen KM,Grill DE,Poland GA |
Exact source |
Suppl Table 1 |
Related gene sets |
(show 3 additional gene sets from the source publication)
(show 30 gene sets from the same authors)
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External links |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946173/bin/mmc1.docx
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
HIPC SIGNATURES (NIAID/HIPC SIGNATURES) |
Source platform or identifier namespace |
HUMAN_GENE_SYMBOL |
Dataset references |
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 9 genes
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Gene families ? |
Categorize these
9 genes by gene family
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Show members |
(show 9 source identifiers mapped to 9 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
ARHGEF10 |
9639 |
ARHGEF10 |
Rho guanine nucleotide exchange factor 1... |
ATP13A4 |
84239 |
ATP13A4 |
ATPase 13A4 [Source:HGNC Symbol;Acc:HGNC... |
CUL1 |
8454 |
CUL1 |
cullin 1 [Source:HGNC Symbol;Acc:HGNC:2551] |
GRPEL2 |
134266 |
GRPEL2 |
GrpE like 2, mitochondrial [Source:HGNC ... |
KAT2B |
8850 |
KAT2B |
lysine acetyltransferase 2B [Source:HGNC... |
MBTPS1 |
8720 |
MBTPS1 |
membrane bound transcription factor pept... |
MIR155HG |
114614 |
MIR155HG |
MIR155 host gene [Source:HGNC Symbol;Acc... |
PHF2 |
5253 |
PHF2 |
PHD finger protein 2 [Source:HGNC Symbol... |
SCRIB |
23513 |
SCRIB |
scribble planar cell polarity protein [S... |
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Version history |
7.3: First Introduced.
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