Standard name |
PENG_GLUCOSE_DEPRIVATION_DN |
Systematic name |
M7970 |
Brief description |
Genes down-regulated in BJAB cells (B-lymphoma) after glucose [PubChem=206] deprivation. |
Full description or abstract |
RAFT1/FRAP/mTOR is a key regulator of cell growth and division and the mammalian target of rapamycin, an immunosuppressive and anticancer drug. Rapamycin deprivation and nutrient deprivation have similar effects on the activity of S6 kinase 1 (S6K1) and 4E-BP1, two downstream effectors of RAFT1, but the relationship between nutrient- and rapamycin-sensitive pathways is unknown. Using transcriptional profiling, we show that, in human BJAB B-lymphoma cells and murine CTLL-2 T lymphocytes, rapamycin treatment affects the expression of many genes involved in nutrient and protein metabolism. The rapamycin-induced transcriptional profile is distinct from those induced by glucose, glutamine, or leucine deprivation but is most similar to that induced by amino acid deprivation. In particular, rapamycin treatment and amino acid deprivation up-regulate genes involved in nutrient catabolism and energy production and down-regulate genes participating in lipid and nucleotide synthesis and in protein synthesis, turnover, and folding. Surprisingly, however, rapamycin had effects opposite from those of amino acid starvation on the expression of a large group of genes involved in the synthesis, transport, and use of amino acids. Supported by measurements of nutrient use, the data suggest that RAFT1 is an energy and nutrient sensor and that rapamycin mimics a signal generated by the starvation of amino acids but that the signal is unlikely to be the absence of amino acids themselves. These observations underscore the importance of metabolism in controlling lymphocyte proliferation and offer a novel explanation for immunosuppression by rapamycin. |
Collection |
ARCHIVED: Archived Founder gene sets that are referenced by current Hallmarks C2_NONE: ARCHIVED Curated C2_CGP: ARCHIVED Chemical and Genetic Perturbations |
Source publication |
Pubmed 12101249 Authors: Peng T,Golub TR,Sabatini DM |
Exact source |
Suppl. data for Fig. 2: sheet8_BJAB_glucose_dw |
Related gene sets |
(show 6 additional gene sets from the source publication)
(show 270 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Pablo Tamayo (MSigDB Team) |
Source platform or identifier namespace |
UniGene_ID |
Dataset references |
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
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Compendia expression profiles ? |
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Advanced query |
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Gene families ? |
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Show members |
(show 173 source identifiers mapped to 0 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
Hs.100030 |
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Hs.100090 |
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Hs.10094 |
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Hs.103283 |
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Hs.107088 |
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Hs.108014 |
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Hs.108110 |
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Hs.108371 |
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Hs.110713 |
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Hs.112255 |
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Hs.113271 |
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Hs.11441 |
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Hs.116206 |
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Hs.11673 |
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Hs.117333 |
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Hs.118962 |
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Hs.121102 |
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Hs.121484 |
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Hs.122575 |
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Hs.123016 |
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Hs.1274 |
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Hs.129208 |
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Hs.129801 |
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Hs.140945 |
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Hs.1435 |
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Hs.143641 |
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Hs.1526 |
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Hs.15265 |
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Hs.153179 |
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Hs.153479 |
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Hs.153937 |
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Hs.155079 |
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Hs.155119 |
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Hs.155210 |
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Hs.155530 |
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Hs.155924 |
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Hs.15744 |
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Hs.158321 |
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Hs.159311 |
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Hs.16003 |
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Hs.1608 |
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Hs.169313 |
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Hs.169474 |
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Hs.170917 |
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Hs.173381 |
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Hs.173518 |
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Hs.173694 |
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Hs.174044 |
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Hs.1741 |
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Hs.177656 |
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Hs.178452 |
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Hs.179526 |
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Hs.179662 |
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Hs.180871 |
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Hs.180900 |
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Hs.180919 |
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Hs.181195 |
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Hs.182536 |
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Hs.184050 |
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Hs.184141 |
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Hs.184270 |
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Hs.184510 |
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Hs.184572 |
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Hs.184915 |
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Hs.18686 |
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Hs.194689 |
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Hs.198249 |
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Hs.198689 |
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Hs.198767 |
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Hs.199179 |
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Hs.20716 |
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Hs.207798 |
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Hs.21 |
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Hs.211580 |
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Hs.21756 |
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Hs.220689 |
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Hs.223025 |
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Hs.227391 |
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Hs.234216 |
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Hs.234759 |
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Hs.239298 |
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Hs.240013 |
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Hs.241375 |
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Hs.250692 |
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Hs.251374 |
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Hs.258587 |
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Hs.25960 |
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Hs.26023 |
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Hs.268384 |
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Hs.272674 |
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Hs.280666 |
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Hs.2841 |
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Hs.28726 |
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Hs.29736 |
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Hs.31210 |
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Hs.31463 |
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Hs.32597 |
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Hs.3426 |
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Hs.3642 |
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Hs.3657 |
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Hs.3833 |
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Hs.42400 |
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Hs.44268 |
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Hs.46038 |
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Hs.48915 |
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Hs.50758 |
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Hs.58189 |
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Hs.5881 |
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Hs.6196 |
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Hs.66542 |
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Hs.68137 |
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Hs.6880 |
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Hs.71331 |
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Hs.72931 |
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Hs.73737 |
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Hs.73769 |
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Hs.73851 |
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Hs.73957 |
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Hs.73965 |
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Hs.73980 |
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Hs.74637 |
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Hs.7476 |
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Hs.75188 |
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Hs.75268 |
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Hs.75290 |
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Hs.75323 |
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Hs.75355 |
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Hs.75367 |
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Hs.75558 |
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Hs.75770 |
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Hs.75842 |
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Hs.75871 |
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Hs.76118 |
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Hs.7719 |
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Hs.77897 |
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Hs.78305 |
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Hs.7885 |
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Hs.78934 |
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Hs.79078 |
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Hs.79101 |
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Hs.79150 |
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Hs.79172 |
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Hs.79241 |
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Hs.79307 |
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Hs.80961 |
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Hs.80976 |
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Hs.81221 |
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Hs.8186 |
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Hs.81964 |
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Hs.82425 |
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Hs.82685 |
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Hs.83347 |
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Hs.84928 |
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Hs.84981 |
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Hs.865 |
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Hs.87465 |
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Hs.8858 |
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Hs.8878 |
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Hs.904 |
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Hs.923 |
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Hs.94 |
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Hs.96055 |
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Hs.96731 |
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Hs.98508 |
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Hs.98614 |
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Version history |
3.0: Renamed from PENG_GLUCOSE_DN
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We need your help: Update on GSEA/MSigDB funding support
Last November we submitted a proposal to NCI's Information Technology for Cancer Research (ITCR) program for the continued
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