Human Gene Set: PETROVA_PROX1_TARGETS_UP


Standard name PETROVA_PROX1_TARGETS_UP
Systematic name M1495
Brief description Genes specific to LEC (lymphatic endothelium cells) induced in BEC (blood endothelium cells) by expression of PROX1 [GeneID=5629] off adenovirus vector.
Full description or abstract Lymphatic vessels are essential for fluid homeostasis, immune surveillance and fat adsorption, and also serve as a major route for tumor metastasis in many types of cancer. We found that isolated human primary lymphatic and blood vascular endothelial cells (LECs and BECs, respectively) show interesting differences in gene expression relevant for their distinct functions in vivo. Although these phenotypes are stable in vitro and in vivo, overexpression of the homeobox transcription factor Prox-1 in the BECs was capable of inducing LEC-specific gene transcription in the BECs, and, surprisingly, Prox-1 suppressed the expression of approximately 40% of the BEC-specific genes. Prox-1 did not have global effects on the expression of LEC-specific genes in other cell types, except that it up-regulated cyclin E1 and E2 mRNAs and activated the cyclin e promoter in various cell types. These data suggest that Prox-1 acts as a cell proliferation inducer and a fate determination factor for the LECs. Furthermore, the data provide insights into the phenotypic diversity of endothelial cells and into the possibility of transcriptional reprogramming of differentiated endothelial cells.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12198161   Authors: Petrova TV,Mäkinen T,Mäkelä TP,Saarela J,Virtanen I,Ferrell RE,Finegold DN,Kerjaschki D,Ylä-Herttuala S,Alitalo K
Exact source Table 2S: LEC-specific induced by AdProx-1
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Source species Homo sapiens
Contributed by Kevin Vogelsang (MSigDB Team)
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identifier namespace		 HUMAN_SEQ_ACCESSION
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Version history 3.1: First introduced

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