Human Gene Set: PULVER_FOREY_PERTURB_ACCUMULATION_LG1


Standard name PULVER_FOREY_PERTURB_ACCUMULATION_LG1
Systematic name M49290
Brief description Genes whose depletion leads to accumulation of cells in lG1 (pVal < 0.05) in K562 Repogle et al., 2022 reanalyzed with Velocycle from Lederer et al., 2024
Full description or abstract Transcription regulation during the cell cycle is crucial for ensuring genes are expressed at the right time and in the correct amounts, coordinating key processes like DNA replication, mitosis, and cell division. In our study, "Evolutionarily Recent Transcription Factors Partake in Human Cell Cycle Regulation" (Pulver & Forey et al., 2024), we analyzed the impact of gene depletion on the cell cycle in K562 cells, These comprehensive data are now accessible for exploration and visualization via a user-friendly web resource.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication  
Exact source TableS4_PerturbSeq.xlsx
Related gene sets  
External links https://tronoapps.epfl.ch/cycleQuest/
Filtered by similarity ?
Source species Homo sapiens
Contributed by Romain Forey (EPFL)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 1102 genes
Gene families ? Categorize these 1102 genes by gene family
Show members (show 1104 source identifiers mapped to 1102 genes)
Version history 2025.1.Hs: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.