Systematic name M41191
Brief description Genes down-regulated in CD4-positive, alpha-beta memory T cell CD4-positive T cell vs naive CD4-positive T cell in seniors (52-75) after exposure to Zostavax , time point 7 to 9D. Comment: Table S3. BV and BJ gene segment usage in VZV-reactive CD4 T cells compared to naive and memory CD4 T cells (FDR <= 0.1).
Full description or abstract Diversity and size of the antigen-specific T cell receptor (TCR) repertoire are two critical determinants for successful control of chronic infection. Varicella zoster virus (VZV) that establishes latency during childhood can escape control mechanisms, in particular with increasing age. We examined the TCR diversity of VZV-reactive CD4 T cells in individuals older than 50 years by studying three identical twin pairs and three unrelated individuals before and after vaccination with live attenuated VZV. Although all individuals had a small number of dominant T cell clones, the breadth of the VZV-specific repertoire differed markedly. A genetic influence was seen for the sharing of individual TCR sequences from antigen-reactive cells but not for repertoire richness or the selection of dominant clones. VZV vaccination favored the expansion of infrequent VZV antigen-reactive TCRs, including those from naive T cells with lesser boosting of dominant T cell clones. Thus, vaccination does not reinforce the in vivo selection that occurred during chronic infection but leads to a diversification of the VZV-reactive T cell repertoire. However, a single-booster immunization seems insufficient to establish new clonal dominance. Our results suggest that repertoire analysis of antigen-specific TCRs can be an important readout to assess whether a vaccination was able to generate memory cells in clonal sizes that are necessary for immune protection.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 27030598   Authors: Qi Q,Cavanagh MM,Le Saux S,NamKoong H,Kim C,Turgano E,Liu Y,Wang C,Mackey S,Swan GE,Dekker CL,Olshen RA,Boyd SD,Weyand CM,Tian L,Goronzy JJ
Exact source Table S3
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(show 79 gene sets from the same authors)
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Organism Homo sapiens
Source platform HUMAN_GENE_SYMBOL
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