Human Gene Set: QI_PBMC_ZOSTAVAX_AGE_50_75YO_CORRELATED
      _WITH_28D_PEAK_T_CELL_RESPONSE_14DY
      _NEGATIVE


Standard name QI_PBMC_ZOSTAVAX_AGE_50_75YO_CORRELATED_WITH_28D_PEAK_T_CELL_RESPONSE_14DY_NEGATIVE
Systematic name M41132
Brief description Genes negatively correlated with peak T cell response 28d in peripheral blood mononuclear cell in seniors (50-75) after exposure to Zostavax, time point 14D. Comment: negative correlation coefficients between gene expression level at day 14 after vaccination and peak to day 28 T cell responses
Full description or abstract Vaccination with attenuated live varicella zoster virus (VZV) can prevent zoster reactivation, but protection is incomplete especially in an older population. To decipher the molecular mechanisms underlying variable vaccine responses, T- and B-cell responses to VZV vaccination were examined in individuals of different ages including identical twin pairs. Contrary to the induction of VZV-specific antibodies, antigen-specific T cell responses were significantly influenced by inherited factors. Diminished generation of long-lived memory T cells in older individuals was mainly caused by increased T cell loss after the peak response while the expansion of antigen-specific T cells was not affected by age. Gene expression in activated CD4 T cells at the time of the peak response identified gene modules related to cell cycle regulation and DNA repair that correlated with the contraction phase of the T cell response and consequently the generation of long-lived memory cells. These data identify cell cycle regulatory mechanisms as targets to reduce T cell attrition in a vaccine response and to improve the generation of antigen-specific T cell memory, in particular in an older population.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 27764254   Authors: Qi Q,Cavanagh MM,Le Saux S,Wagar LE,Mackey S,Hu J,Maecker H,Swan GE,Davis MM,Dekker CL,Tian L,Weyand CM,Goronzy JJ
Exact source Fig 7B
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(show 33 gene sets from the same authors)
External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072604/figure/ppat.1005892.g007/
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Organism Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: First Introduced.

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