Human Gene Set: QI_PBMC_ZOSTAVAX_AGE_50_75YO_CORRELATED
      _WITH_T_CELL_RESPONSES_1D_INFORMATIVE
      _OF_LONG_TERM_RESPONSES_NEGATIVE


Standard name QI_PBMC_ZOSTAVAX_AGE_50_75YO_CORRELATED_WITH_T_CELL_RESPONSES_1D_INFORMATIVE_OF_LONG_TERM_RESPONSES_NEGATIVE
Systematic name M40988
Brief description Genes negatively correlated with T cell responses (long term) in peripheral blood mononuclear cell in seniors (50-75) after exposure to Zostavax , time point 1D. Comment: (B) Network of genes informative of long-term responses.
Full description or abstract Vaccination with attenuated live varicella zoster virus (VZV) can prevent zoster reactivation, but protection is incomplete especially in an older population. To decipher the molecular mechanisms underlying variable vaccine responses, T- and B-cell responses to VZV vaccination were examined in individuals of different ages including identical twin pairs. Contrary to the induction of VZV-specific antibodies, antigen-specific T cell responses were significantly influenced by inherited factors. Diminished generation of long-lived memory T cells in older individuals was mainly caused by increased T cell loss after the peak response while the expansion of antigen-specific T cells was not affected by age. Gene expression in activated CD4 T cells at the time of the peak response identified gene modules related to cell cycle regulation and DNA repair that correlated with the contraction phase of the T cell response and consequently the generation of long-lived memory cells. These data identify cell cycle regulatory mechanisms as targets to reduce T cell attrition in a vaccine response and to improve the generation of antigen-specific T cell memory, in particular in an older population.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 27764254   Authors: Qi Q,Cavanagh MM,Le Saux S,Wagar LE,Mackey S,Hu J,Maecker H,Swan GE,Davis MM,Dekker CL,Tian L,Weyand CM,Goronzy JJ
Exact source Suppl Fig 2B
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External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072604/bin/ppat.1005892.s008.docx
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Organism Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: First Introduced.

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