Systematic name M41133
Brief description Genes that are components of a model predictive of response in peripheral blood mononuclear cell 3d vs 0d in adults (18-45) after exposure to YF-17D vaccine , time point 3D. Comment: Suppl Table 4: genes validated by ClaNC as being predictive of CD8+ T cell responses from Fig. 4.
Full description or abstract A major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we have used a systems biology approach to identify early gene 'signatures' that predicted immune responses in humans vaccinated with yellow fever vaccine YF-17D. Vaccination induced genes that regulate virus innate sensing and type I interferon production. Computational analyses identified a gene signature, including complement protein C1qB and eukaryotic translation initiation factor 2 alpha kinase 4-an orchestrator of the integrated stress response-that correlated with and predicted YF-17D CD8(+) T cell responses with up to 90% accuracy in an independent, blinded trial. A distinct signature, including B cell growth factor TNFRS17, predicted the neutralizing antibody response with up to 100% accuracy. These data highlight the utility of systems biology approaches in predicting vaccine efficacy.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 19029902   Authors: Querec TD,Akondy RS,Lee EK,Cao W,Nakaya HI,Teuwen D,Pirani A,Gernert K,Deng J,Marzolf B,Kennedy K,Wu H,Bennouna S,Oluoch H,Miller J,Vencio RZ,Mulligan M,Aderem A,Ahmed R,Pulendran B
Exact source Fig 4 & Suppl Table 4
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Organism Homo sapiens
Source platform HUMAN_GENE_SYMBOL
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