Human Gene Set: QUEREC_PBMC_YF_17D_VACCINE_AGE_18_45YO_3DY_UP


Standard name QUEREC_PBMC_YF_17D_VACCINE_AGE_18_45YO_3DY_UP
Systematic name M41047
Brief description Genes up-regulated in peripheral blood mononuclear cell 3d vs 0d in adults (18-45) after exposure to YF-17D vaccine , time point 3D
Full description or abstract A major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we have used a systems biology approach to identify early gene 'signatures' that predicted immune responses in humans vaccinated with yellow fever vaccine YF-17D. Vaccination induced genes that regulate virus innate sensing and type I interferon production. Computational analyses identified a gene signature, including complement protein C1qB and eukaryotic translation initiation factor 2 alpha kinase 4-an orchestrator of the integrated stress response-that correlated with and predicted YF-17D CD8(+) T cell responses with up to 90% accuracy in an independent, blinded trial. A distinct signature, including B cell growth factor TNFRS17, predicted the neutralizing antibody response with up to 100% accuracy. These data highlight the utility of systems biology approaches in predicting vaccine efficacy.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 19029902   Authors: Querec TD,Akondy RS,Lee EK,Cao W,Nakaya HI,Teuwen D,Pirani A,Gernert K,Deng J,Marzolf B,Kennedy K,Wu H,Bennouna S,Oluoch H,Miller J,Vencio RZ,Mulligan M,Aderem A,Ahmed R,Pulendran B
Exact source Fig1 & Suppl Fig 3
Related gene sets (show 37 additional gene sets from the source publication)

(show 301 gene sets from the same authors)
External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049462/bin/NIHMS593578-supplement-01.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049462/figure/F1/
Filtered by similarity ?
Organism Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
Source platform HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 46 genes
Gene families ? Categorize these 46 genes by gene family
Show members (show 47 members mapped to 46 genes)
Version history 7.3: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.