Human Gene Set: RHODES_CANCER_META_SIGNATURE


Standard name RHODES_CANCER_META_SIGNATURE
Systematic name M1345
Brief description Genes commonly up-regulated in cancer relative to normal tissue, according to the meta-analysis of the OncoMine gene expression database.
Full description or abstract Many studies have used DNA microarrays to identify the gene expression signatures of human cancer, yet the critical features of these often unmanageably large signatures remain elusive. To address this, we developed a statistical method, comparative metaprofiling, which identifies and assesses the intersection of multiple gene expression signatures from a diverse collection of microarray data sets. We collected and analyzed 40 published cancer microarray data sets, comprising 38 million gene expression measurements from >3,700 cancer samples. From this, we characterized a common transcriptional profile that is universally activated in most cancer types relative to the normal tissues from which they arose, likely reflecting essential transcriptional features of neoplastic transformation. In addition, we characterized a transcriptional profile that is commonly activated in various types of undifferentiated cancer, suggesting common molecular mechanisms by which cancer cells progress and avoid differentiation. Finally, we validated these transcriptional profiles on independent data sets.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15184677   Authors: Rhodes DR,Yu J,Shanker K,Deshpande N,Varambally R,Ghosh D,Barrette T,Pandey A,Chinnaiyan AM
Exact source Fig. 2A
Related gene sets (show 1 additional gene sets from the source publication)

(show 51 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by John Newman (University of Washington)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 65 genes
Gene families ? Categorize these 65 genes by gene family
Show members (show 67 source identifiers mapped to 65 genes)
Version history 3.0: Renamed from CANCER_NEOPLASTIC_META_UP

See MSigDB license terms here. Please note that certain gene sets have special access terms.