Human Gene Set: SANA_TNF_SIGNALING_DN


Standard name SANA_TNF_SIGNALING_DN
Systematic name M19467
Brief description Genes down-regulated in five primary endothelial cell types (lung, aortic, iliac, dermal, and colon) by TNF [GeneID=7124].
Full description or abstract To investigate the potential molecular mediators of tissue-specific recruitment, we explored the influence of different cytokine challenges on gene expression regulation in five primary endothelial cells (ECs), representing two different phenotypes: iliac artery and aortic (macrovascular); lung, colon and dermal (microvascular). We challenged ECs with cytokines that elicit different patterns of inflammatory and immune responses in immune cells: tumor necrosis factor (TNF-alpha), interferon-gamma (IFN-gamma) or interleukin-4 (IL-4), and used microarrays containing approximately 40,000 unique cDNAs, to assess changes in differential gene expression relative to untreated cells. Five hundred and sixty three sequences changed by at least 2.5 fold in one or more of the 15 possible EC /cytokine combinations. The list included highly regulated adhesion molecules, chemokines, cytokines, metalloproteases, and IFN-gamma-induced genes. Overall, IFN-gamma caused the largest number of gene expression changes and its profile was least correlated with IL-4. In addition to clusters that were predominantly EC/cytokine specific, we also observed several clusters that were regulated by more than one cytokine across several ECs. Furthermore, we identified genes that were reciprocally expressed in response to different cytokines that could serve as markers of inflammatory and immune expression. These results confirm the importance of microenvironment in primary ECs that could have important applications in developing targeted therapies for vascular diseases.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15749026   Authors: Sana TR,Janatpour MJ,Sathe M,McEvoy LM,McClanahan TK
Exact source GSE569: bottom 100 from COLON_TNFA DERMAL_TNFA ILIAC_TNFA AORTIC_TNFA LUNG_TNFA
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Source species Homo sapiens
Contributed by Yujin Hoshida (Broad Institute)
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identifier namespace		 HUMAN_SEQ_ACCESSION
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