Human Gene Set: SASAKI_ADULT_T_CELL_LEUKEMIA


Standard name SASAKI_ADULT_T_CELL_LEUKEMIA
Systematic name M15171
Brief description Genes up-regulated in adult T-cell leukemia (ATL) cells compared to T lymphocytes from healthy controls.
Full description or abstract Adult T-cell leukemia (ATL) caused by human T-cell leukemia virus type 1 (HTLV-1) infection, occurs in 2% to 4% of the HTLV-1 carriers with a long latent period, suggesting that additional alterations participate in the development of ATL. To characterize and identify novel markers of ATL, we examined the expression profiles of more than 12 000 genes in 8 cases of acute-type ATL using microarray. One hundred ninety-two genes containing interleukin 2 (IL-2) receptor alpha were up-regulated more than 2-fold compared with CD4(+) and CD4(+)CD45RO(+) T cells, and tumor suppressor in lung cancer 1 (TSLC1), caveolin 1, and prostaglandin D2 synthase showed increased expression of more than 30-fold. TSLC1 is a cell adhesion molecule originally identified as a tumor suppressor in the lung but lacks its expression in normal or activated T cells. We confirmed ectopic expression of the TSLC1 in all acute-type ATL cells and in 7 of 10 ATL- or HTLV-1-infected T-cell lines. Introduction of TSLC1 into a human ATL cell line ED enhanced both self-aggregation and adhesion ability to vascular endothelial cells. These results suggested that the ectopic expression of TSLC1 could provide a novel marker for acute-type ATL and may participate in tissue invasion, a characteristic feature of the malignant ATL cells.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15471956   Authors: Sasaki H,Nishikata I,Shiraga T,Akamatsu E,Fukami T,Hidaka T,Kubuki Y,Okayama A,Hamada K,Okabe H,Murakami Y,Tsubouchi H,Morishita K
Exact source Table 2
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Source species Homo sapiens
Contributed by Kate Stafford (MSigDB Team)
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identifier namespace		 HUMAN_SEQ_ACCESSION
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Version history 3.0: Renamed from SASAKI_TCELL_LYMPHOMA_VS_CD4_UP

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