Human Gene Set: SAUL_SEN_MAYO

For the Mouse gene set with the same name, see SAUL_SEN_MAYO

Standard name SAUL_SEN_MAYO
Systematic name M45803
Brief description Genes upregulated in senescent cells: Senescence-associated secretory phenotype (SASP).
Full description or abstract Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell identification remains challenging. Here, we generate a gene set (SenMayo) and validate its enrichment in bone biopsies from two aged human cohorts. We further demonstrate reductions in SenMayo in bone following genetic clearance of senescent cells in mice and in adipose tissue from humans following pharmacological senescent cell clearance. We next use SenMayo to identify senescent hematopoietic or mesenchymal cells at the single cell level from human and murine bone marrow/bone scRNA-seq data. Thus, SenMayo identifies senescent cells across tissues and species with high fidelity. Using this senescence panel, we are able to characterize senescent cells at the single cell level and identify key intercellular signaling pathways. SenMayo also represents a potentially clinically applicable panel for monitoring senescent cell burden with aging and other conditions as well as in studies of senolytic drugs.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 35974106   Authors: Saul D,Kosinsky RL,Atkinson EJ,Doolittle ML,Zhang X,LeBrasseur NK,Pignolo RJ,Robbins PD,Niedernhofer LJ,Ikeno Y,Jurk D,Passos JF,Hickson LJ,Xue A,Monroe DG,Tchkonia T,Kirkland JL,Farr JN,Khosla S
Exact source Supplementary Data 1
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Source species Homo sapiens
Contributed by Dominik Saul (Mayo Clinic Rochester, MN, USA)
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Version history 2023.1.Hs: First Introduced.

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