Standard name |
SMID_BREAST_CANCER_LUMINAL_A_DN |
Systematic name |
M13072 |
Brief description |
Genes down-regulated in the luminal A subtype of breast cancer. |
Full description or abstract |
We explored whether the five previously reported molecular subtypes in breast cancer show a preference for organ-specific relapse and searched for molecular pathways involved. The intrinsic gene list describing the subtypes was used to classify 344 primary breast tumors of lymph node-negative patients. Fisher exact tests were used to determine the association between a tumor subtype and a particular site of distant relapse in these patients who only received local treatment. Modulated genes and pathways were identified in the various groups using Significance Analysis of Microarrays and Global Testing. Bone relapse patients were most abundant in the luminal subtypes but were found less than expected in the basal subtype. The reverse was true for lung and brain relapse patients with the remark that absence of lung relapse was luminal A specific. Finally, a pleura relapse, although rare, was found almost exclusively in both luminal subtypes. Many differentially expressed genes were identified, of which several were in common in a subtype and the site to which the subtype preferentially relapsed. WNT signaling was up-regulated in the basal subtype and in brain-specific relapse, and down-modulated in the luminal B subtype and in bone-specific relapse. Focal adhesion was found up-regulated in the luminal A subtype but down-regulated in lung relapse. The five major molecular subtypes in breast cancer are evidently different with regard to their ability to metastasize to distant organ(s), and share biological features and pathways with their preferred distant metastatic site. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 18451135 Authors: Smid M,Wang Y,Zhang Y,Sieuwerts AM,Yu J,Klijn JG,Foekens JA,Martens JW |
Exact source |
Fig 1S: luminal A down |
Related gene sets |
(show 19 additional gene sets from the source publication)
(show 93 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Jessica Robertson (MSigDB Team) |
Source platform or identifier namespace |
AFFY_HG_U133 |
Dataset references |
(show 2 datasets)
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
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these 18 genes
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Gene families ? |
Categorize these
18 genes by gene family
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Show members |
(show 18 source identifiers mapped to 18 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
201195_s_at |
8140 |
SLC7A5 |
solute carrier family 7 member 5 [Source... |
201291_s_at |
7153 |
TOP2A |
DNA topoisomerase II alpha [Source:HGNC ... |
201710_at |
4605 |
MYBL2 |
MYB proto-oncogene like 2 [Source:HGNC S... |
202870_s_at |
991 |
CDC20 |
cell division cycle 20 [Source:HGNC Symb... |
203702_s_at |
9654 |
TTLL4 |
tubulin tyrosine ligase like 4 [Source:H... |
204126_s_at |
8318 |
CDC45 |
cell division cycle 45 [Source:HGNC Symb... |
204162_at |
10403 |
NDC80 |
NDC80 kinetochore complex component [Sou... |
208103_s_at |
81611 |
ANP32E |
acidic nuclear phosphoprotein 32 family ... |
208433_s_at |
7804 |
LRP8 |
LDL receptor related protein 8 [Source:H... |
209800_at |
3868 |
KRT16 |
keratin 16 [Source:HGNC Symbol;Acc:HGNC:... |
210052_s_at |
22974 |
TPX2 |
TPX2 microtubule nucleation factor [Sour... |
212949_at |
23397 |
NCAPH |
non-SMC condensin I complex subunit H [S... |
213523_at |
898 |
CCNE1 |
cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1... |
215729_s_at |
51442 |
VGLL1 |
vestigial like family member 1 [Source:H... |
216212_s_at |
1736 |
DKC1 |
dyskerin pseudouridine synthase 1 [Sourc... |
219555_s_at |
55839 |
CENPN |
centromere protein N [Source:HGNC Symbol... |
221436_s_at |
83461 |
CDCA3 |
cell division cycle associated 3 [Source... |
221520_s_at |
55143 |
CDCA8 |
cell division cycle associated 8 [Source... |
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Version history |
3.0: First introduced
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We need your help: Update on GSEA/MSigDB funding support
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