Human Gene Set: SMIRNOV_RESPONSE_TO_IR_6HR_UP


Standard name SMIRNOV_RESPONSE_TO_IR_6HR_UP
Systematic name M2588
Brief description Genes up-regulated in B lymphocytes at 6 h after exprosure to 10 Gy dose of ionizing radiation.
Full description or abstract Radiation exposure through environmental, medical, and occupational settings is increasingly common. While radiation has harmful effects, it has utility in many applications such as radiotherapy for cancer. To increase the efficacy of radiation treatment and minimize its risks, a better understanding of the individual differences in radiosensitivity and the molecular basis of radiation response is needed. Here, we integrated human genetic and functional genomic approaches to study the response of human cells to radiation. We measured radiation-induced changes in gene expression and cell death in B cells from normal individuals. We found extensive individual variation in gene expression and cellular responses. To understand the genetic basis of this variation, we mapped the DNA sequence variants that influence expression response to radiation. We also identified radiation-responsive genes that regulate cell death; silencing of these genes by small interfering RNA led to an increase in radiation-induced cell death in human B cells, colorectal and prostate cancer cells. Together these results uncovered DNA variants that contribute to radiosensitivity and identified genes that can be targeted to increase the sensitivity of tumors to radiation.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 21844125   Authors: Smirnov DA,Brady L,Halasa K,Morley M,Solomon S,Cheung VG
Exact source Table 1S: Current Study 6hr avg log2 fold change >= 0.58
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Organism Homo sapiens
Contributed by Itai Pashtan (Dana-Farber Cancer Institute)
Source platform AFFY_HG_U133
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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