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Human Gene Set: SOBOLEV_PBMC_PANDEMRIX_AGE_18_64YO_LOW
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| Standard name | SOBOLEV_PBMC_PANDEMRIX_AGE_18_64YO_LOW_VS_MEDIUM_HIGH_ADVERSE_EVENT_SUBJECTS_0DY_DN |
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| Systematic name | M41016 |
| Brief description | Genes down-regulated in peripheral blood mononuclear cell -7d vs 0d in adults (18-64) (low AE subjects vs medium/high AE subjects) after exposure to Pandemrix (A/California/7/09 (H1N1)) , time point 0D |
| Full description or abstract | Adjuvanted vaccines afford invaluable protection against disease, and the molecular and cellular changes they induce offer direct insight into human immunobiology. Here we show that within 24 h of receiving adjuvanted swine flu vaccine, healthy individuals made expansive, complex molecular and cellular responses that included overt lymphoid as well as myeloid contributions. Unexpectedly, this early response was subtly but significantly different in people older than ~35 years. Wide-ranging adverse clinical events can seriously confound vaccine adoption, but whether there are immunological correlates of these is unknown. Here we identify a molecular signature of adverse events that was commonly associated with an existing B cell phenotype. Thus immunophenotypic variation among healthy humans may be manifest in complex pathophysiological responses. |
| Collection | C7: Immunologic Signature VAX: HIPC Vaccine Response |
| Source publication | Pubmed 26726811 Authors: Sobolev O,Binda E,O'Farrell S,Lorenc A,Pradines J,Huang Y,Duffner J,Schulz R,Cason J,Zambon M,Malim MH,Peakman M,Cope A,Capila I,Kaundinya GV,Hayday AC |
| Exact source | Suppl. Fig 8 |
| Related gene sets |
(show 10 additional gene sets from the source publication)
(show 20 gene sets from any of these authors) |
| External links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485475/bin/NIHMS65741-supplement-1.pdf |
| Filtered by similarity ? | |
| Source species | Homo sapiens |
| Contributed by | HIPC SIGNATURES (NIAID/HIPC SIGNATURES) |
| Source platform or identifier namespace |
HUMAN_GENE_SYMBOL |
| Dataset references | |
| Download gene set | format: grp | gmt | xml | json | TSV metadata |
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NG-CHM interactive heatmaps (Please note that clustering takes a few seconds) Legacy heatmaps (PNG) |
| Advanced query | Further investigate these 8 genes |
| Gene families ? | Categorize these 8 genes by gene family |
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(show 8 source identifiers mapped to 8 genes)
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| Version history | 7.3: First Introduced. |
