Systematic name M41206
Brief description Genes down-regulated in T cell 7d vs 1d in adults (18-64) after exposure to Pandemrix (A/California/7/09 (H1N1)) , time point 7D. Comment: - roughly 60/40 female:male ratio, over 70% were Causasian
Full description or abstract Adjuvanted vaccines afford invaluable protection against disease, and the molecular and cellular changes they induce offer direct insight into human immunobiology. Here we show that within 24 h of receiving adjuvanted swine flu vaccine, healthy individuals made expansive, complex molecular and cellular responses that included overt lymphoid as well as myeloid contributions. Unexpectedly, this early response was subtly but significantly different in people older than ~35 years. Wide-ranging adverse clinical events can seriously confound vaccine adoption, but whether there are immunological correlates of these is unknown. Here we identify a molecular signature of adverse events that was commonly associated with an existing B cell phenotype. Thus immunophenotypic variation among healthy humans may be manifest in complex pathophysiological responses.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 26726811   Authors: Sobolev O,Binda E,O'Farrell S,Lorenc A,Pradines J,Huang Y,Duffner J,Schulz R,Cason J,Zambon M,Malim MH,Peakman M,Cope A,Capila I,Kaundinya GV,Hayday AC
Exact source Fig2c
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