Systematic name M45007
Brief description Metabolic related genes that showed positive correlation with MYC expression in CRC tissues
Full description or abstract Our transcriptome analyses of paired normal and tumor tissues from 41 patients with colorectal cancer showed that metabolic reprogramming of colorectal cancer is caused chiefly by aberrant MYC expression, which induced at least 215 metabolic reactions by changing the expression levels of metabolic genes and transporter genes. Further, MYC negatively regulated the expression of genes involved in mitochondrial biogenesis and maintenance but positively regulated genes involved in DNA and histone methylation. Knockdown of MYC in colorectal cancer cells reset the altered metabolism and suppressed cell growth.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 28847964   Authors: Satoh K,Yachida S,Sugimoto M,Oshima M,Nakagawa T,Akamoto S,Tabata S,Saitoh K,Kato K,Sato S,Igarashi K,Aizawa Y,Kajino-Sakamoto R,Kojima Y,Fujishita T,Enomoto A,Hirayama A,Ishikawa T,Taketo MM,Kushida Y,Haba R,Okano K,Tomita M,Suzuki Y,Fukuda S,Aoki M,Soga T
Exact source Table S3: Candidate MYC target metabolic genes
Related gene sets (show 1 additional gene sets from the source publication)

(show 8 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Rintaro Saito (Institute for Advanced Biosciences, Keio University)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 2022.1.Hs: Renamed from SATOH_COLORECTAL_CANCER_MYC_UP

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