Human Gene Set: STAMBOLSKY_BOUND_BY_MUTATED_TP53


Standard name STAMBOLSKY_BOUND_BY_MUTATED_TP53
Systematic name M2100
Brief description Gene promoters preferentially bound by a mutated form of TP53 [GeneID=7157] in SKBR3 cells (breast cancer).
Full description or abstract The p53 gene is mutated in many human tumors. Cells of such tumors often contain abundant mutant p53 (mutp53) protein, which may contribute actively to tumor progression via a gain-of-function mechanism. We applied ChIP-on-chip analysis and identified the vitamin D receptor (VDR) response element as overrepresented in promoter sequences bound by mutp53. We report that mutp53 can interact functionally and physically with VDR. Mutp53 is recruited to VDR-regulated genes and modulates their expression, augmenting the transactivation of some genes and relieving the repression of others. Furthermore, mutp53 increases the nuclear accumulation of VDR. Importantly, mutp53 converts vitamin D into an antiapoptotic agent. Thus, p53 status can determine the biological impact of vitamin D on tumor cells.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 20227041   Authors: Stambolsky P,Tabach Y,Fontemaggi G,Weisz L,Maor-Aloni R,Siegfried Z,Shiff I,Kogan I,Shay M,Kalo E,Blandino G,Simon I,Oren M,Rotter V
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 Human_RefSeq
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Version history 3.1: First introduced

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