Human Gene Set: STONER_ESOPHAGEAL_CARCINOGENESIS_DN


Standard name STONER_ESOPHAGEAL_CARCINOGENESIS_DN
Systematic name M1444
Brief description Genes down-regulated in esophagus by the carcinogen NMBA [PubChem=13643] and brought back to normal by a diet with PEITC [PubChem=16741] or black raspberries.
Full description or abstract Our recent study identified 2,261 dysregulated genes in the esophagi of rats that received a 1-week exposure to the carcinogen N-nitrosomethylbenzylamine (NMBA). We further reported that 1,323 of these genes were positively modulated to near-normal levels of expression in NMBA-treated animals that consumed dietary phenylethyl isothiocyanate (PEITC), a constituent of cruciferous vegetables. Herein, we report our results with companion animals that were fed a diet containing 5% freeze-dried black raspberries (BRB) instead of PEITC. We found that 462 of the 2,261 NMBA-dysregulated genes in rat esophagus were restored to near-normal levels of expression by BRB. Further, we have identified 53 NMBA-dysregulated genes that are positively modulated by both PEITC and BRB. These 53 common genes include genes involved in phase I and II metabolism, oxidative damage, and oncogenes and tumor suppressor genes that regulate apoptosis, cell cycling, and angiogenesis. Because both PEITC and BRB maintain near-normal levels of expression of these 53 genes, their dysregulation during the early phase of NMBA-induced esophageal cancer may be especially important in the genesis of the disease.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18676871   Authors: Stoner GD,Dombkowski AA,Reen RK,Cukovic D,Salagrama S,Wang LS,Lechner JF
Exact source Table 2: NMBA vs control < 0
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Source species Rattus norvegicus
Contributed by Jessica Robertson (MSigDB Team)
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identifier namespace		 Rat_NCBI_Gene_ID
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Version history 3.1: First introduced

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