Human Gene Set: TAN_CRC_NECROPTOSIS_RELATED_GENES


Standard name TAN_CRC_NECROPTOSIS_RELATED_GENES
Systematic name M50227
Brief description The NRG (Necroptosis-Related Gene) signature is an 18-gene transcriptional model designed for the prognostic stratification and immunological profiling of colorectal cancer (CRC).
Full description or abstract The NRG signature effectively classifies patients into high-risk and low-risk categories based on a calculated risk score. The low-risk group is significantly associated with an immune hot phenotype, characterized by high infiltration of cytotoxic T cells, NK cells, and the upregulation of 14 HLA-related antigens, as well as higher immune checkpoint activity. The high-risk group reflects an immune cold microenvironment with lower overall immune and TIDE scores. The signature's prognostic accuracy was validated across three independent cohorts (TCGA-COAD, GSE38832, and GSE161158), where a nomogram integrating the NRG score with AJCC staging achieved an AUC of 0.811 for 5-year overall survival.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 40959081   Authors: Tan L,Wang S,Chang W,Zhang X,Deng R,Yan H,Zhu W,Wang H,Cai Y,Liu Z,Tan Y,Cui J
Exact source NRG Signature as provided in study abstract
Related gene sets (show 438 gene sets from any of these authors)
External links https://doi.org/10.3389/fimmu.2025.1619749
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Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 2026.1.Hs: First Introduced.


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