Human Gene Set: TCGA_GLIOBLASTOMA_COPY_NUMBER_DN


Standard name TCGA_GLIOBLASTOMA_COPY_NUMBER_DN
Systematic name M5520
Brief description Genes down-regulated and displaying decreased copy number in glioblastoma samples.
Full description or abstract Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community. Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas--the most common type of adult brain cancer--and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol-3-OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma. Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18772890   Authors: Cancer Genome Atlas Research Network
Exact source Table 2S: reduced expression and deletion
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Source species Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
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Version history 3.0: First introduced

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