Human Gene Set: THALER_BONE60


Standard name THALER_BONE60
Systematic name M49141
Brief description Genes selectively higher expressed in human and mouse bone tissue compared to a series of other muskuloskeltal and non muskuloskeletal human and mouse tissues
Full description or abstract For the definition of Bone60 gene-set raw-files own as well as from publically available RNA-Seq datasets from different human and/or control wildtype mouse tissues were downloaded from the NCBI-SRA database, assessed for read quality with fastqc version 0.72 and analyzed by organism. To further normalize for possible batch effects between the samples, RUVSeq was applied in conjunction with DESeq2. Bone tissue-related gene-sets as defined by DESeq2 and including already well-known bone related genes, were then compared between human and mouse and only genes found in both organisms were selected for the final gene-sets.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 36202795   Authors: Thaler R,Khani F,Sturmlechner I,Dehghani SS,Denbeigh JM,Zhou X,Pichurin O,Dudakovic A,Jerez SS,Zhong J,Lee JH,Natarajan R,Kalajzic I,Jiang YH,Deyle DR,Paschalis EP,Misof BM,Ordog T,van Wijnen AJ
Exact source Supp. Fig 1f: Definition of Bone60 gene-set
Related gene sets (show 72 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Roman Thaler (Mayo Clinic, Rochester, MN)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 60 genes
Gene families ? Categorize these 60 genes by gene family
Show members (show 60 source identifiers mapped to 60 genes)
Version history 2025.1.Hs: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.