Human Gene Set: TOMLINS_METASTASIS_DN


Standard name TOMLINS_METASTASIS_DN
Systematic name M7090
Brief description Top genes down-regulated in hormone refractory metastatic prostate cancer compared to localized prostate cancer.
Full description or abstract Despite efforts to profile prostate cancer, the genetic alterations and biological processes that correlate with the observed histological progression are unclear. Using laser-capture microdissection to isolate 101 cell populations, we have profiled prostate cancer progression from benign epithelium to metastatic disease. By analyzing expression signatures in the context of over 14,000 'molecular concepts', or sets of biologically connected genes, we generated an integrative model of progression. Molecular concepts that demarcate critical transitions in progression include protein biosynthesis, E26 transformation-specific (ETS) family transcriptional targets, androgen signaling and cell proliferation. Of note, relative to low-grade prostate cancer (Gleason pattern 3), high-grade cancer (Gleason pattern 4) shows an attenuated androgen signaling signature, similar to metastatic prostate cancer, which may reflect dedifferentiation and explain the clinical association of grade with prognosis. Taken together, these data show that analyzing gene expression signatures in the context of a compendium of molecular concepts is useful in understanding cancer biology.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17173048   Authors: Tomlins SA,Mehra R,Rhodes DR,Cao X,Wang L,Dhanasekaran SM,Kalyana-Sundaram S,Wei JT,Rubin MA,Pienta KJ,Shah RB,Chinnaiyan AM
Exact source Fig 5aS: right panel
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Source species Homo sapiens
Contributed by Leona Saunders (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 3.0: First introduced

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