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Human Gene Set: TSANG_PBMC_FLUVIRIN_PANDEMRIX_ADULT
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| Standard name | TSANG_PBMC_FLUVIRIN_PANDEMRIX_ADULT_CORR_WITH_CELL_FREQ_CD27HI_CD38HI_CD20_NEG_PLASMABLASTS_AND_CD38PLUS_OF_IGD_CD27PLUS_MEM_B_CELLS_7DY_POSITIVE |
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| Systematic name | M41196 |
| Brief description | Genes positively correlated with cell frequency CD27hi CD38hi of CD20- B cells (Plasmablasts) and CD38+ of IgD-CD27+ memory B cells in peripheral blood mononuclear cell in adults after exposure to Fluvirin/Pandemrix , time point 7D |
| Full description or abstract | A major goal of systems biology is the development of models that accurately predict responses to perturbation. Constructing such models requires the collection of dense measurements of system states, yet transformation of data into predictive constructs remains a challenge. To begin to model human immunity, we analyzed immune parameters in depth both at baseline and in response to influenza vaccination. Peripheral blood mononuclear cell transcriptomes, serum titers, cell subpopulation frequencies, and B cell responses were assessed in 63 individuals before and after vaccination and were used to develop a systematic framework to dissect inter- and intra-individual variation and build predictive models of postvaccination antibody responses. Strikingly, independent of age and pre-existing antibody titers, accurate models could be constructed using pre-perturbation cell populations alone, which were validated using independent baseline time points. Most of the parameters contributing to prediction delineated temporally stable baseline differences across individuals, raising the prospect of immune monitoring before intervention. |
| Collection | C7: Immunologic Signature VAX: HIPC Vaccine Response |
| Source publication | Pubmed 24725414 Authors: Tsang JS,Schwartzberg PL,Kotliarov Y,Biancotto A,Xie Z,Germain RN,Wang E,Olnes MJ,Narayanan M,Golding H,Moir S,Dickler HB,Perl S,Cheung F,Baylor HIPC Center,CHI Consortium |
| Exact source | Fig 7 |
| Related gene sets |
(show 45 gene sets from the same authors)
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| External links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139290/figure/F7/ |
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| Source species | Homo sapiens |
| Contributed by | HIPC SIGNATURES (NIAID/HIPC SIGNATURES) |
| Source platform or identifier namespace |
HUMAN_GENE_SYMBOL |
| Dataset references | |
| Download gene set | format: grp | gmt | xml | json | TSV metadata |
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| Compendia expression profiles ? |
NG-CHM interactive heatmaps (Please note that clustering takes a few seconds) Legacy heatmaps (PNG) |
| Advanced query | Further investigate these 78 genes |
| Gene families ? | Categorize these 78 genes by gene family |
| Show members |
(show 78 source identifiers mapped to 78 genes)
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| Version history | 7.3: First Introduced. |
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