Systematic name M2115
Brief description Genes correlated with proneural type of glioblastoma multiforme tumors.
Full description or abstract The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 20129251   Authors: Verhaak RG,Hoadley KA,Purdom E,Wang V,Qi Y,Wilkerson MD,Miller CR,Ding L,Golub T,Mesirov JP,Alexe G,Lawrence M,O'Kelly M,Tamayo P,Weir BA,Gabriel S,Winckler W,Gupta S,Jakkula L,Feiler HS,Hodgson JG,James CD,Sarkaria JN,Brennan C,Kahn A,Spellman PT,Wilson RK,Speed TP,Gray JW,Meyerson M,Getz G,Perou CM,Hayes DN,Cancer Genome Atlas Research Network
Exact source TCGA_unified_CORE_ClaNC840.txt GO genes = PN
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Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform HUMAN_GENE_SYMBOL
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