Human Gene Set: WALLACE_PROSTATE_CANCER_RACE_DN


Standard name WALLACE_PROSTATE_CANCER_RACE_DN
Systematic name M15671
Brief description Genes down-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients.
Full description or abstract The incidence and mortality rates of prostate cancer are significantly higher in African-American men when compared with European-American men. We tested the hypothesis that differences in tumor biology contribute to this survival health disparity. Using microarray technology, we obtained gene expression profiles of primary prostate tumors resected from 33 African-American and 36 European-American patients. These tumors were matched on clinical variables. We also evaluated 18 nontumor prostate tissues from seven African-American and 11 European-American patients. The resulting datasets were analyzed for expression differences on the gene and pathway level comparing African-American with European-American patients. Our analysis revealed a significant number of genes, e.g., 162 transcripts at a false-discovery rate of
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18245496   Authors: Wallace TA,Prueitt RL,Yi M,Howe TM,Gillespie JW,Yfantis HG,Stephens RM,Caporaso NE,Loffredo CA,Ambs S
Exact source Table 2S
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Source species Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
Source platform or
identifier namespace		 AFFY_HG_U133
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Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: First introduced

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