Standard name |
WANG_METASTASIS_OF_BREAST_CANCER |
Systematic name |
M2084 |
Brief description |
Genes whose expression in primary ER(-) [GeneID=2099] breast cancer tumors negatively correlates with developing distant metastases. |
Full description or abstract |
BACKGROUND: Genome-wide measures of gene expression can identify patterns of gene activity that subclassify tumours and might provide a better means than is currently available for individual risk assessment in patients with lymph-node-negative breast cancer. METHODS: We analysed, with Affymetrix Human U133a GeneChips, the expression of 22000 transcripts from total RNA of frozen tumour samples from 286 lymph-node-negative patients who had not received adjuvant systemic treatment. FINDINGS: In a training set of 115 tumours, we identified a 76-gene signature consisting of 60 genes for patients positive for oestrogen receptors (ER) and 16 genes for ER-negative patients. This signature showed 93% sensitivity and 48% specificity in a subsequent independent testing set of 171 lymph-node-negative patients. The gene profile was highly informative in identifying patients who developed distant metastases within 5 years (hazard ratio 5.67 [95% CI 2.59-12.4]), even when corrected for traditional prognostic factors in multivariate analysis (5.55 [2.46-12.5]). The 76-gene profile also represented a strong prognostic factor for the development of metastasis in the subgroups of 84 premenopausal patients (9.60 [2.28-40.5]), 87 postmenopausal patients (4.04 [1.57-10.4]), and 79 patients with tumours of 10-20 mm (14.1 [3.34-59.2]), a group of patients for whom prediction of prognosis is especially difficult. INTERPRETATION: The identified signature provides a powerful tool for identification of patients at high risk of distant recurrence. The ability to identify patients who have a favourable prognosis could, after independent confirmation, allow clinicians to avoid adjuvant systemic therapy or to choose less aggressive therapeutic options. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 15721472 Authors: Wang Y,Klijn JG,Zhang Y,Sieuwerts AM,Look MP,Yang F,Talantov D,Timmermans M,Meijer-van Gelder ME,Yu J,Jatkoe T,Berns EM,Atkins D,Foekens JA |
Exact source |
Table 2: ER-negative group, Cox < 0 |
Related gene sets |
(show 2 additional gene sets from the source publication)
(show 110 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Arthur Liberzon (MSigDB Team) |
Source platform or identifier namespace |
AFFY_HG_U133 |
Dataset references |
(show 1 datasets)
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 16 genes
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Gene families ? |
Categorize these
16 genes by gene family
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Show members |
(show 16 source identifiers mapped to 16 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
202239_at |
143 |
PARP4 |
poly(ADP-ribose) polymerase family me... |
202687_s_at |
8743 |
TNFSF10 |
TNF superfamily member 10 [Source:HGN... |
204218_at |
25906 |
ANAPC15 |
anaphase promoting complex subunit 15... |
204631_at |
4620 |
MYH2 |
myosin heavy chain 2 [Source:HGNC Sym... |
205848_at |
2620 |
GAS2 |
growth arrest specific 2 [Source:HGNC... |
209862_s_at |
9702 |
CEP57 |
centrosomal protein 57 [Source:HGNC S... |
210593_at |
23053 |
ZSWIM8 |
zinc finger SWIM-type containing 8 [S... |
214915_at |
149076 |
ZNF362 |
zinc finger protein 362 [Source:HGNC ... |
216010_x_at |
2525 |
FUT3 |
fucosyltransferase 3 (Lewis blood gro... |
216103_at |
26027 |
ACOT11 |
acyl-CoA thioesterase 11 [Source:HGNC... |
217019_at |
128580 |
RPS4XP3 |
ribosomal protein S4X pseudogene 3 [S... |
217404_s_at |
1280 |
COL2A1 |
collagen type II alpha 1 chain [Sourc... |
218430_s_at |
64864 |
RFX7 |
regulatory factor X7 [Source:HGNC Sym... |
220886_at |
55879 |
GABRQ |
gamma-aminobutyric acid type A recept... |
221241_s_at |
79370 |
BCL2L14 |
BCL2 like 14 [Source:HGNC Symbol;Acc:... |
221634_at |
54029 |
RPL23AP4 |
ribosomal protein L23a pseudogene 4 [... |
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Version history |
3.1: First introduced
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