Human Gene Set: WANG_METASTASIS_OF_BREAST_CANCER


Standard name WANG_METASTASIS_OF_BREAST_CANCER
Systematic name M2084
Brief description Genes whose expression in primary ER(-) [GeneID=2099] breast cancer tumors negatively correlates with developing distant metastases.
Full description or abstract BACKGROUND: Genome-wide measures of gene expression can identify patterns of gene activity that subclassify tumours and might provide a better means than is currently available for individual risk assessment in patients with lymph-node-negative breast cancer. METHODS: We analysed, with Affymetrix Human U133a GeneChips, the expression of 22000 transcripts from total RNA of frozen tumour samples from 286 lymph-node-negative patients who had not received adjuvant systemic treatment. FINDINGS: In a training set of 115 tumours, we identified a 76-gene signature consisting of 60 genes for patients positive for oestrogen receptors (ER) and 16 genes for ER-negative patients. This signature showed 93% sensitivity and 48% specificity in a subsequent independent testing set of 171 lymph-node-negative patients. The gene profile was highly informative in identifying patients who developed distant metastases within 5 years (hazard ratio 5.67 [95% CI 2.59-12.4]), even when corrected for traditional prognostic factors in multivariate analysis (5.55 [2.46-12.5]). The 76-gene profile also represented a strong prognostic factor for the development of metastasis in the subgroups of 84 premenopausal patients (9.60 [2.28-40.5]), 87 postmenopausal patients (4.04 [1.57-10.4]), and 79 patients with tumours of 10-20 mm (14.1 [3.34-59.2]), a group of patients for whom prediction of prognosis is especially difficult. INTERPRETATION: The identified signature provides a powerful tool for identification of patients at high risk of distant recurrence. The ability to identify patients who have a favourable prognosis could, after independent confirmation, allow clinicians to avoid adjuvant systemic therapy or to choose less aggressive therapeutic options.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15721472   Authors: Wang Y,Klijn JG,Zhang Y,Sieuwerts AM,Look MP,Yang F,Talantov D,Timmermans M,Meijer-van Gelder ME,Yu J,Jatkoe T,Berns EM,Atkins D,Foekens JA
Exact source Table 2: ER-negative group, Cox < 0
Related gene sets (show 2 additional gene sets from the source publication)

(show 110 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 AFFY_HG_U133
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 16 genes
Gene families ? Categorize these 16 genes by gene family
Show members (show 16 source identifiers mapped to 16 genes)
Version history 3.1: First introduced

A big thank you to everyone who responded to our request for emails of support for our grant application resubmission.
Reading them made us feel so appreciated and valued by all of you.

We hope we can continue to bring you GSEA/MSigDB in the years to come.
-The GSEA/MSigDB Team


See MSigDB license terms here. Please note that certain gene sets have special access terms.