Standard name |
WANG_METASTASIS_OF_BREAST_CANCER_ESR1_DN |
Systematic name |
M2083 |
Brief description |
Genes whose expression in primary ER(+) [GeneID=2099] breast cancer tumors negatively correlates with developing distant metastases. |
Full description or abstract |
BACKGROUND: Genome-wide measures of gene expression can identify patterns of gene activity that subclassify tumours and might provide a better means than is currently available for individual risk assessment in patients with lymph-node-negative breast cancer. METHODS: We analysed, with Affymetrix Human U133a GeneChips, the expression of 22000 transcripts from total RNA of frozen tumour samples from 286 lymph-node-negative patients who had not received adjuvant systemic treatment. FINDINGS: In a training set of 115 tumours, we identified a 76-gene signature consisting of 60 genes for patients positive for oestrogen receptors (ER) and 16 genes for ER-negative patients. This signature showed 93% sensitivity and 48% specificity in a subsequent independent testing set of 171 lymph-node-negative patients. The gene profile was highly informative in identifying patients who developed distant metastases within 5 years (hazard ratio 5.67 [95% CI 2.59-12.4]), even when corrected for traditional prognostic factors in multivariate analysis (5.55 [2.46-12.5]). The 76-gene profile also represented a strong prognostic factor for the development of metastasis in the subgroups of 84 premenopausal patients (9.60 [2.28-40.5]), 87 postmenopausal patients (4.04 [1.57-10.4]), and 79 patients with tumours of 10-20 mm (14.1 [3.34-59.2]), a group of patients for whom prediction of prognosis is especially difficult. INTERPRETATION: The identified signature provides a powerful tool for identification of patients at high risk of distant recurrence. The ability to identify patients who have a favourable prognosis could, after independent confirmation, allow clinicians to avoid adjuvant systemic therapy or to choose less aggressive therapeutic options. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 15721472 Authors: Wang Y,Klijn JG,Zhang Y,Sieuwerts AM,Look MP,Yang F,Talantov D,Timmermans M,Meijer-van Gelder ME,Yu J,Jatkoe T,Berns EM,Atkins D,Foekens JA |
Exact source |
Table 2: ER-positive group, Cox < 0 |
Related gene sets |
(show 2 additional gene sets from the source publication)
(show 110 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Arthur Liberzon (MSigDB Team) |
Source platform or identifier namespace |
AFFY_HG_U133 |
Dataset references |
(show 1 datasets)
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 32 genes
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Gene families ? |
Categorize these
32 genes by gene family
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Show members |
(show 36 source identifiers mapped to 32 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
200965_s_at |
3983 |
ABLIM1 |
actin binding LIM protein 1 [Sour... |
201288_at |
397 |
ARHGDIB |
Rho GDP dissociation inhibitor be... |
201368_at |
678 |
ZFP36L2 |
ZFP36 ring finger protein like 2 ... |
203306_s_at |
10559 |
SLC35A1 |
solute carrier family 35 member A... |
203391_at |
2286 |
FKBP2 |
FKBP prolyl isomerase 2 [Source:H... |
204014_at |
1846 |
DUSP4 |
dual specificity phosphatase 4 [S... |
204015_s_at |
1846 |
DUSP4 |
dual specificity phosphatase 4 [S... |
204740_at |
10256 |
CNKSR1 |
connector enhancer of kinase supp... |
204888_s_at |
9148 |
NEURL1 |
neuralized E3 ubiquitin protein l... |
206295_at |
3606 |
IL18 |
interleukin 18 [Source:HGNC Symbo... |
207118_s_at |
8510 |
MMP23B |
matrix metallopeptidase 23B [Sour... |
208683_at |
824 |
CAPN2 |
calpain 2 [Source:HGNC Symbol;Acc... |
209500_x_at |
8741 |
TNFSF13 |
TNF superfamily member 13 [Source... |
209835_x_at |
960 |
CD44 |
CD44 molecule (Indian blood group... |
210028_s_at |
23595 |
ORC3 |
origin recognition complex subuni... |
210314_x_at |
8741 |
TNFSF13 |
TNF superfamily member 13 [Source... |
211382_s_at |
10579 |
TACC2 |
transforming acidic coiled-coil c... |
211779_x_at |
161 |
AP2A2 |
adaptor related protein complex 2... |
212014_x_at |
960 |
CD44 |
CD44 molecule (Indian blood group... |
212567_s_at |
4134 |
MAP4 |
microtubule associated protein 4 ... |
214806_at |
636 |
BICD1 |
BICD cargo adaptor 1 [Source:HGNC... |
214919_s_at |
8637 |
EIF4EBP3 |
eukaryotic translation initiation... |
215510_at |
2116 |
ETV2 |
ETS variant transcription factor ... |
215633_x_at |
7940 |
LST1 |
leukocyte specific transcript 1 [... |
217102_at |
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217471_at |
101928104 |
LINC01482 |
long intergenic non-protein codin... |
217767_at |
718 |
C3 |
complement C3 [Source:HGNC Symbol... |
217771_at |
51280 |
GOLM1 |
golgi membrane protein 1 [Source:... |
218914_at |
51093 |
METTL25B |
methyltransferase like 25B [Sourc... |
219340_s_at |
2055 |
CLN8 |
CLN8 transmembrane ER and ERGIC p... |
219724_s_at |
9840 |
TESPA1 |
thymocyte expressed, positive sel... |
221028_s_at |
81577 |
GFOD2 |
glucose-fructose oxidoreductase d... |
221344_at |
26529 |
OR12D2 |
olfactory receptor family 12 subf... |
221816_s_at |
51131 |
PHF11 |
PHD finger protein 11 [Source:HGN... |
221916_at |
4747 |
NEFL |
neurofilament light chain [Source... |
221928_at |
32 |
ACACB |
acetyl-CoA carboxylase beta [Sour... |
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Version history |
3.1: First introduced
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