Standard name |
WANG_METASTASIS_OF_BREAST_CANCER_ESR1_UP |
Systematic name |
M2082 |
Brief description |
Genes whose expression in primary ER(+) [GeneID=2099] breast cancer tumors positively correlates with developing distant metastases. |
Full description or abstract |
BACKGROUND: Genome-wide measures of gene expression can identify patterns of gene activity that subclassify tumours and might provide a better means than is currently available for individual risk assessment in patients with lymph-node-negative breast cancer. METHODS: We analysed, with Affymetrix Human U133a GeneChips, the expression of 22000 transcripts from total RNA of frozen tumour samples from 286 lymph-node-negative patients who had not received adjuvant systemic treatment. FINDINGS: In a training set of 115 tumours, we identified a 76-gene signature consisting of 60 genes for patients positive for oestrogen receptors (ER) and 16 genes for ER-negative patients. This signature showed 93% sensitivity and 48% specificity in a subsequent independent testing set of 171 lymph-node-negative patients. The gene profile was highly informative in identifying patients who developed distant metastases within 5 years (hazard ratio 5.67 [95% CI 2.59-12.4]), even when corrected for traditional prognostic factors in multivariate analysis (5.55 [2.46-12.5]). The 76-gene profile also represented a strong prognostic factor for the development of metastasis in the subgroups of 84 premenopausal patients (9.60 [2.28-40.5]), 87 postmenopausal patients (4.04 [1.57-10.4]), and 79 patients with tumours of 10-20 mm (14.1 [3.34-59.2]), a group of patients for whom prediction of prognosis is especially difficult. INTERPRETATION: The identified signature provides a powerful tool for identification of patients at high risk of distant recurrence. The ability to identify patients who have a favourable prognosis could, after independent confirmation, allow clinicians to avoid adjuvant systemic therapy or to choose less aggressive therapeutic options. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 15721472 Authors: Wang Y,Klijn JG,Zhang Y,Sieuwerts AM,Look MP,Yang F,Talantov D,Timmermans M,Meijer-van Gelder ME,Yu J,Jatkoe T,Berns EM,Atkins D,Foekens JA |
Exact source |
Table 2: ER-positive group, Cox > 0 |
Related gene sets |
(show 2 additional gene sets from the source publication)
(show 110 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Homo sapiens |
Contributed by |
Arthur Liberzon (MSigDB Team) |
Source platform or identifier namespace |
AFFY_HG_U133 |
Dataset references |
(show 1 datasets)
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 22 genes
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Gene families ? |
Categorize these
22 genes by gene family
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Show members |
(show 24 source identifiers mapped to 22 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
200726_at |
5501 |
PPP1CC |
protein phosphatase 1 catalytic subunit... |
201068_s_at |
5701 |
PSMC2 |
proteasome 26S subunit, ATPase 2 [Sourc... |
201091_s_at |
11335 |
CBX3 |
chromobox 3 [Source:HGNC Symbol;Acc:HGN... |
201663_s_at |
10051 |
SMC4 |
structural maintenance of chromosomes 4... |
201664_at |
10051 |
SMC4 |
structural maintenance of chromosomes 4... |
202240_at |
5347 |
PLK1 |
polo like kinase 1 [Source:HGNC Symbol;... |
202418_at |
10897 |
YIF1A |
Yip1 interacting factor homolog A, memb... |
204073_s_at |
745 |
MYRF |
myelin regulatory factor [Source:HGNC S... |
204540_at |
1917 |
EEF1A2 |
eukaryotic translation elongation facto... |
204768_s_at |
2237 |
FEN1 |
flap structure-specific endonuclease 1 ... |
205034_at |
9134 |
CCNE2 |
cyclin E2 [Source:HGNC Symbol;Acc:HGNC:... |
208180_s_at |
8365 |
H4C8 |
H4 clustered histone 8 [Source:HGNC Sym... |
209524_at |
50810 |
HDGFL3 |
HDGF like 3 [Source:HGNC Symbol;Acc:HGN... |
211040_x_at |
51512 |
GTSE1 |
G2 and S-phase expressed 1 [Source:HGNC... |
211762_s_at |
3838 |
KPNA2 |
karyopherin subunit alpha 2 [Source:HGN... |
216693_x_at |
50810 |
HDGFL3 |
HDGF like 3 [Source:HGNC Symbol;Acc:HGN... |
217815_at |
11198 |
SUPT16H |
SPT16 homolog, facilitates chromatin re... |
218478_s_at |
55596 |
ZCCHC8 |
zinc finger CCHC-type containing 8 [Sou... |
218533_s_at |
54963 |
UCKL1 |
uridine-cytidine kinase 1 like 1 [Sourc... |
218782_s_at |
29028 |
ATAD2 |
ATPase family AAA domain containing 2 [... |
218883_s_at |
79682 |
CENPU |
centromere protein U [Source:HGNC Symbo... |
219510_at |
10721 |
POLQ |
DNA polymerase theta [Source:HGNC Symbo... |
219588_s_at |
54892 |
NCAPG2 |
non-SMC condensin II complex subunit G2... |
221882_s_at |
58986 |
PGAP6 |
post-GPI attachment to proteins 6 [Sour... |
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Version history |
3.1: First introduced
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