Human Gene Set: WEI_TELOMERE_RELATED_HNSCC_PROGNOSTIC_SIGNATURE


Standard name WEI_TELOMERE_RELATED_HNSCC_PROGNOSTIC_SIGNATURE
Systematic name M50228
Brief description Telomere-related genes forming a composite risk score whose higher values are associated with poorer overall survival in head and neck squamous cell carcinoma.
Full description or abstract This gene set represents a 24-gene telomere-related gene (TRG) signature developed to predict the prognosis and immune landscape of head and neck squamous cell carcinoma (HNSCC). Using machine learning on data from TCGA and GEO, researchers established a risk-scoring model that classifies patients into high- and low-risk categories. The signature demonstrated strong predictive accuracy, with 3-year and 5-year survival ROC AUC values of 0.734 and 0.711, respectively. Patients in the low-risk group exhibited significantly better survival outcomes, characterized by higher immune scores, increased immune cell infiltration, and a superior response to immunotherapy. Furthermore, through Mendelian randomization, the study identified a potential causal link between MAD1L1 expression and HNSCC development.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 40258723   Authors: Wei Z,Hu Y,Zhang Y,Wang G,Zhou C,Wang Y
Exact source https://links.lww.com/MD/O694
Related gene sets (show 184 gene sets from any of these authors)
External links https://pmc.ncbi.nlm.nih.gov/articles/PMC12014034/
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Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 2026.1.Hs: First Introduced.


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