Human Gene Set: YAGI_AML_WITH_T_8_21_TRANSLOCATION


Standard name YAGI_AML_WITH_T_8_21_TRANSLOCATION
Systematic name M19261
Brief description Genes specifically expressed in samples from patients with pediatric AML (acute myeloid leukemia ) bearing t(8;21) translocation.
Full description or abstract Most patients with acute myeloid leukemia (AML) enter complete remission (CR) after treatment with chemotherapy, but a large number of them experience relapse with resistant disease. To identify genes that are associated with their prognoses, we analyzed gene expression in 54 pediatric patients with AML using an oligonucleotide microarray that contained 12 566 probe sets. A supervised approach using the Student t test selected a prognostic set of 35 genes, some of which are associated with the regulation of cell cycle and apoptosis. Most of these genes had not previously been reported to be associated with prognosis and were not correlated with morphologically classified French-American-British (FAB) subtypes or with karyotypes. These results indicate the existence of prognosis-associated genes that are independent of cell lineage and cytogenetic abnormalities, and they can provide therapeutic direction for individual risk-adapted therapy for pediatric AML patients.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12738660   Authors: Yagi T,Morimoto A,Eguchi M,Hibi S,Sako M,Ishii E,Mizutani S,Imashuku S,Ohki M,Ichikawa H
Exact source Table 4S: t(8;21)-specific probe sets (424 probe sets)
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 AFFY_HG_U95
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Human tissue compendium (Novartis)
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NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: First introduced

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