Human Gene Set: ZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE
      _20_50YO_CORRELATED_WITH_CD8_T_CELL
      _RESPONSE_3DY_POSITIVE


Standard name ZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_CORRELATED_WITH_CD8_T_CELL_RESPONSE_3DY_POSITIVE
Systematic name M40895
Brief description Genes positively correlated with CD8+ T-cell response in peripheral blood mononuclear cell in adults (20-50) after exposure to MRKAd5 HIV-1 gag/pol/nef , time point 3D
Full description or abstract To better understand how innate immune responses to vaccination can lead to lasting protective immunity, we used a systems approach to define immune signatures in humans over 1 wk following MRKAd5/HIV vaccination that predicted subsequent HIV-specific T-cell responses. Within 24 h, striking increases in peripheral blood mononuclear cell gene expression associated with inflammation, IFN response, and myeloid cell trafficking occurred, and lymphocyte-specific transcripts decreased. These alterations were corroborated by marked serum inflammatory cytokine elevations and egress of circulating lymphocytes. Responses of vaccinees with preexisting adenovirus serotype 5 (Ad5) neutralizing antibodies were strongly attenuated, suggesting that enhanced HIV acquisition in Ad5-seropositive subgroups in the Step Study may relate to the lack of appropriate innate activation rather than to increased systemic immune activation. Importantly, patterns of chemoattractant cytokine responses at 24 h and alterations in 209 peripheral blood mononuclear cell transcripts at 72 h were predictive of subsequent induction and magnitude of HIV-specific CD8(+) T-cell responses. This systems approach provides a framework to compare innate responses induced by vectors, as shown here by contrasting the more rapid, robust response to MRKAd5/HIV with that to yellow fever vaccine. When applied iteratively, the findings may permit selection of HIV vaccine candidates eliciting innate immune response profiles more likely to drive HIV protective immunity.
Collection C7: Immunologic Signature
      VAX: HIPC Vaccine Response
Source publication Pubmed 23151505   Authors: Zak DE,Andersen-Nissen E,Peterson ER,Sato A,Hamilton MK,Borgerding J,Krishnamurty AT,Chang JT,Adams DJ,Hensley TR,Salter AI,Morgan CA,Duerr AC,De Rosa SC,Aderem A,McElrath MJ
Exact source Suppl Table 14
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External links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528489/bin/1208972109_sd01.xlsx
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Organism Homo sapiens
Contributed by HIPC SIGNATURES (NIAID/HIPC SIGNATURES)
Source platform HUMAN_GENE_SYMBOL
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Version history 7.3: First Introduced.

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