Standard name |
ZHANG_GATA6_TARGETS_UP |
Systematic name |
M1777 |
Brief description |
Genes up-regulated after cre-lox knockout of GATA6 [GeneID=2627] in airway epithelium. |
Full description or abstract |
Epithelial organs, including the lung, are known to possess regenerative abilities through activation of endogenous stem cell populations, but the molecular pathways regulating stem cell expansion and regeneration are not well understood. Here we show that Gata6 regulates the temporal appearance and number of bronchioalveolar stem cells (BASCs) in the lung, its absence in Gata6-null lung epithelium leading to the precocious appearance of BASCs and concurrent loss in epithelial differentiation. This expansion of BASCs was the result of a pronounced increase in canonical Wnt signaling in lung epithelium upon loss of Gata6. Expression of the noncanonical Wnt receptor Fzd2 was downregulated in Gata6 mutants and increased Fzd2 or decreased beta-catenin expression rescued, in part, the lung epithelial defects in Gata6 mutants. During lung epithelial regeneration, canonical Wnt signaling was activated in the niche containing BASCs and forced activation of Wnt signaling led to a large increase in BASC numbers. Moreover, Gata6 was required for proper lung epithelial regeneration, and postnatal loss of Gata6 led to increased BASC expansion and decreased differentiation. Together, these data demonstrate that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 18536717 Authors: Zhang Y,Goss AM,Cohen ED,Kadzik R,Lepore JJ,Muthukumaraswamy K,Yang J,DeMayo FJ,Whitsett JA,Parmacek MS,Morrisey EE |
Exact source |
Fig 4a |
Related gene sets |
(show 1 additional gene sets from the source publication)
(show 84 gene sets from the same authors)
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External links |
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Filtered by similarity ?
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Source species |
Mus musculus |
Contributed by |
Jessica Robertson (MSigDB Team) |
Source platform or identifier namespace |
MOUSE_GENE_SYMBOL |
Dataset references |
(show 1 datasets)
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Download gene set |
format: grp | gmt | xml | json | TSV metadata |
Compute overlaps ? |
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Compendia expression profiles ? |
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Advanced query |
Further investigate
these 16 genes
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Gene families ? |
Categorize these
16 genes by gene family
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Show members |
(show 17 source identifiers mapped to 16 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
Aox3 |
107126360 |
AOX3P |
aldehyde oxidase 3, pseudogene [Sou... |
Aqp4 |
361 |
AQP4 |
aquaporin 4 [Source:HGNC Symbol;Acc... |
Arsk |
153642 |
ARSK |
arylsulfatase family member K [Sour... |
Cab391 |
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Cd36 |
948 |
CD36 |
CD36 molecule [Source:HGNC Symbol;A... |
Dsc2 |
1824 |
DSC2 |
desmocollin 2 [Source:HGNC Symbol;A... |
Emb |
133418 |
EMB |
embigin [Source:HGNC Symbol;Acc:HGN... |
Fabp4 |
2167 |
FABP4 |
fatty acid binding protein 4 [Sourc... |
Fut9 |
10690 |
FUT9 |
fucosyltransferase 9 [Source:HGNC S... |
Galnt13 |
114805 |
GALNT13 |
polypeptide N-acetylgalactosaminylt... |
Gsto1 |
9446 |
GSTO1 |
glutathione S-transferase omega 1 [... |
MGI:1930803 |
54997 |
TESC |
tescalcin [Source:HGNC Symbol;Acc:H... |
Maob |
4129 |
MAOB |
monoamine oxidase B [Source:HGNC Sy... |
Mettl7a1 |
25840 |
METTL7A |
methyltransferase like 7A [Source:H... |
Mpzl2 |
10205 |
MPZL2 |
myelin protein zero like 2 [Source:... |
Pof1b |
79983 |
POF1B |
POF1B actin binding protein [Source... |
Rpl17 |
6139 |
RPL17 |
ribosomal protein L17 [Source:HGNC ... |
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Version history |
3.1: First introduced
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