Systematic name M2606
Brief description Cell cycle genes significantly (p =< 0.05) changed in fibroblast cells at 6 h after exposure to ionizing radiation.
Full description or abstract The changes in global gene expression in response to DNA damage may derive from either direct induction or repression by transcriptional regulation or indirectly by synchronization of cells to specific cell cycle phases, such as G1 or G2. We developed a model that successfully estimated the expression levels of >400 cell cycle-regulated genes in normal human fibroblasts based on the proportions of cells in each phase of the cell cycle. By isolating effects on the gene expression associated with the cell cycle phase redistribution after genotoxin treatment, the direct transcriptional target genes were distinguished from genes for which expression changed secondary to cell synchronization. Application of this model to ionizing radiation (IR)-treated normal human fibroblasts identified 150 of 406 cycle-regulated genes as putative direct transcriptional targets of IR-induced DNA damage. Changes in expression of these genes after IR treatment derived from both direct transcriptional regulation and cell cycle synchronization.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17404513   Authors: Zhou T,Chou J,Mullen TE,Elkon R,Zhou Y,Simpson DA,Bushel PR,Paules RS,Lobenhofer EK,Hurban P,Kaufmann WK
Exact source Table 9S: 'Target' sheet: P_6h =< 0.05
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Source species Homo sapiens
Contributed by Itai Pashtan (Dana-Farber Cancer Institute)
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Version history 3.1: First introduced

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