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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Mm" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_BARRESTIN_PATHWAY" SYSTEMATIC_NAME="MM1501" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/mouse/m_bArrestinPathway.gif" CHIP="MOUSE_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="b-arrestins in GPCR Desensitization" DESCRIPTION_FULL="Role of -arrestins in the desensitization, sequestration and intracellular trafficking of GPCRs. Homologous desensitization of GPCRs (1) results from the binding of -arrestins (-arr) to agonist -occupied receptors following phosphorylation of the receptor by GRKs. -arrestin binding sterically precludes coupling between the receptor and heterotrimeric G proteins, leading to termination of signaling by G proteins effectors. Receptor-bound -arrestins also act as adapter proteins, binding to components of the clathrin endocytic machinery including clathrin, 2-adaptin (AP-2). Receptor sequestration (2) reflects the dynamin (Dyn)-dependent endocytosis of GPCRs via clathrin-coated pits. Once internalized, GPCRs exhibit two distinct patterns of -arrestin interaction. `Class A' GPCRs, for example the 2 adrenergic receptor, rapidly dissociate from -arrestin upon internalization. These receptors are trafficked to an acidified endosomal compartment, wherein the ligand is dissociated and the receptor dephosphorylated by a GPCR-specific protein phosphatase PP2A isoform, and are subsequently recycled to the plasma membrane (3). `Class B' receptors, for example the angiotensin II AT1a receptor, form stable receptor--arrestin complexes. These receptors accumulate in endocytic vesicles and are either targeted for degradation or slowly recycled to the membrane via as yet poorly defined routes." TAGS="" MEMBERS="NM_001077264,NM_001113418,NM_001145830,NM_008417,NM_008418,NM_009622,NM_010065,NM_019690,NM_021275,NM_130863,NM_178220" MEMBERS_SYMBOLIZED="Adcy1,Ap2a1,Arrb1,Dnm1,Gnas,Grk2,Kcna2,Kcna3,Kcna4,Plcb1,Ppara" MEMBERS_EZID="109689,110355,11771,13429,14683,16490,16491,16492,18795,19013,432530" MEMBERS_MAPPING="NM_001077264,Ap2a1,11771|NM_001113418,Ppara,19013|NM_001145830,Plcb1,18795|NM_008417,Kcna2,16490|NM_008418,Kcna3,16491|NM_009622,Adcy1,432530|NM_010065,Dnm1,13429|NM_019690,Gnas,14683|NM_021275,Kcna4,16492|NM_130863,Grk2,110355|NM_178220,Arrb1,109689" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="M2" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
