STANDARD_NAME BIOCARTA_D4GDI_PATHWAY SYSTEMATIC_NAME MM1380 COLLECTION M2:CP:BIOCARTA MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/mouse/geneset/BIOCARTA_D4GDI_PATHWAY NAMESPACE MOUSE_SEQ_ACCESSION DESCRIPTION_BRIEF D4-GDI Signaling Pathway DESCRIPTION_FULL D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras related Rho Family of GTPases. Since the rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kDa mature form of D4-GDI to give a 5 kDa and 23 kDa Size fragment. The 23 kDa fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-Terminal kinase, a regulator of apoptosis, may be one of the mechanisms. PMID GEOID AUTHORS CONTRIBUTOR BioCarta CONTRIBUTOR_ORG BioCarta EXACT_SOURCE FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/mouse/m_d4gdiPathway.gif SOURCE_MEMBERS AK039081,AK041016,NM_001080126,NM_007415,NM_007486,NM_007808,NM_009684,NM_009706,NM_009807,NM_009810,NM_010591,NM_011073,NM_013542,NM_015733 GENE_SYMBOLS Arhgap5,Arhgap5,Casp8,Parp1,Arhgdib,Cycs,Apaf1,Arhgap5,Casp1,Casp3,Jun,Prf1,Gzmb,Casp9 FOUNDER_NAMES