STANDARD_NAME	BIOCARTA_IL22BP_PATHWAY
SYSTEMATIC_NAME	MM1419
COLLECTION	M2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/mouse/geneset/BIOCARTA_IL22BP_PATHWAY
NAMESPACE	MOUSE_SEQ_ACCESSION
DESCRIPTION_BRIEF	IL22 Soluble Receptor Signaling Pathway
DESCRIPTION_FULL	IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surface receptor composed of IL-22R1 and IL-10R2C. One of the actions of IL-22 appears to be the induction of the acute phase inflammatory response in hetapocytes, acting through activation of STATs and transcriptional regulation. A gene with homology to the extracellular domain of the cell surface IL-22R1 receptor component was identified that lacked transmembrane and cytoplasmic domains. The protein derived from this gene was found to bind IL-22 and block its interaction with the cell surface receptor. The IL-22 soluble receptor (IL-22BP, IL-22 binding protein) also blocks some of the downstream effects of IL-22 such as STAT activation and the transcriptional induction of genes involved in the immune and inflammatory responses. The IL-22 soluble receptor may act as an anti-inflammatory agent.
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CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
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EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/mouse/m_il22bpPathway.gif
SOURCE_MEMBERS	AK134154,AK157458,NM_001048177,NM_001113563,NM_001164062,NM_001190830,NM_001205313,NM_007707,NM_011486,NM_018793,NM_146145
GENE_SYMBOLS	Tyk2,Stat1,Jak2,Stat5b,Stat5a,Jak3,Stat1,Socs3,Stat3,Tyk2,Jak1
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