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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Mm" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_IL22BP_PATHWAY" SYSTEMATIC_NAME="MM1419" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/mouse/m_il22bpPathway.gif" CHIP="MOUSE_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="IL22 Soluble Receptor Signaling Pathway" DESCRIPTION_FULL="IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surface receptor composed of IL-22R1 and IL-10R2C. One of the actions of IL-22 appears to be the induction of the acute phase inflammatory response in hetapocytes, acting through activation of STATs and transcriptional regulation. A gene with homology to the extracellular domain of the cell surface IL-22R1 receptor component was identified that lacked transmembrane and cytoplasmic domains. The protein derived from this gene was found to bind IL-22 and block its interaction with the cell surface receptor. The IL-22 soluble receptor (IL-22BP, IL-22 binding protein) also blocks some of the downstream effects of IL-22 such as STAT activation and the transcriptional induction of genes involved in the immune and inflammatory responses. The IL-22 soluble receptor may act as an anti-inflammatory agent." TAGS="" MEMBERS="AK134154,AK157458,NM_001048177,NM_001113563,NM_001164062,NM_001190830,NM_001205313,NM_007707,NM_011486,NM_018793,NM_146145" MEMBERS_SYMBOLIZED="Jak1,Jak2,Jak3,Socs3,Stat1,Stat3,Stat5a,Stat5b,Tyk2" MEMBERS_EZID="12702,16451,16452,16453,20846,20848,20850,20851,54721" MEMBERS_MAPPING="AK134154,Tyk2,54721|AK157458,Stat1,20846|NM_001048177,Jak2,16452|NM_001113563,Stat5b,20851|NM_001164062,Stat5a,20850|NM_001190830,Jak3,16453|NM_001205313,Stat1,20846|NM_007707,Socs3,12702|NM_011486,Stat3,20848|NM_018793,Tyk2,54721|NM_146145,Jak1,16451" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="M2" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
