STANDARD_NAME	BIOCARTA_P38MAPK_PATHWAY
SYSTEMATIC_NAME	MM1450
COLLECTION	M2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/mouse/geneset/BIOCARTA_P38MAPK_PATHWAY
NAMESPACE	MOUSE_SEQ_ACCESSION
DESCRIPTION_BRIEF	p38 MAPK Signaling Pathway
DESCRIPTION_FULL	p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/mouse/M_p38mapkPathway.gif
SOURCE_MEMBERS	AK081384,AK155158,AK157458,AK207894,BG694441,BU515502,NM_001033161,NM_001037726,NM_001099624,NM_001146176,NM_001164708,NM_001168513,NM_001177353,NM_001205313,NM_001243769,NM_007829,NM_007837,NM_007922,NM_008163,NM_008251,NM_008284,NM_008551,NM_008580,NM_009068,NM_009157,NM_009367,NM_009368,NM_009370,NM_009422,NM_009715,NM_010765,NM_011577,NM_011943,NM_011945,NM_013560,NM_021461,NM_172688
GENE_SYMBOLS	Cdc42,Shc1,Stat1,Mapkapk2,,,Tradd,Creb1,Rapgef2,Max,Hspb2,Mapk14,Myc,Stat1,Cdc42,Daxx,Ddit3,Elk1,Grb2,Hmgn1,Hras,Mapkapk2,Map3k5,Ripk1,Map2k4,Tgfb2,Tgfb3,Tgfbr1,Traf2,Atf2,Mapkapk5,Tgfb1,Map2k6,Map3k1,Hspb1,Mknk1,Map3k7
FOUNDER_NAMES