STANDARD_NAME	BIOCARTA_PYK2_PATHWAY
SYSTEMATIC_NAME	MM1431
COLLECTION	M2:CP:BIOCARTA
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/mouse/geneset/BIOCARTA_PYK2_PATHWAY
NAMESPACE	MOUSE_SEQ_ACCESSION
DESCRIPTION_BRIEF	Links between Pyk2 and Map Kinases
DESCRIPTION_FULL	This diagram is a compilation of Pyk2 effort cascades. In specific cell types the receptor and effoectors will vary. Binding of a transmembrane receptor triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and further to the small G protein Rac1. In turn, Rac1 initiatates the JNK cascade, starting with PAK follwed by MEKK1, SEK1, and JNK. JNK activation causes induction of c-Jun gene binding. Pyk2 stimulation has also been shown to activate MKK3 leading to activation of p38. The other major mitogen activated kinase cascade for ERK1/2 is stimulated via RAS, RAF and MEKK1/2.
PMID	
GEOID	
AUTHORS	
CONTRIBUTOR	BioCarta
CONTRIBUTOR_ORG	BioCarta
EXACT_SOURCE	
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/mouse/m_pyk2Pathway.gif
SOURCE_MEMBERS	AK136923,AK155158,BC023080,BG694441,BU515502,BY761703,GH455388,NM_001038663,NM_001162366,NM_001168513,NM_001198839,NM_007590,NM_007764,NM_008139,NM_008163,NM_008284,NM_008855,NM_008927,NM_008928,NM_009157,NM_009231,NM_009790,NM_010591,NM_011035,NM_011101,NM_011945,NM_011952,NM_016700,NM_021280,NM_023138,NM_029780
GENE_SYMBOLS	,Shc1,Crkl,,,,,Mapk1,Ptk2b,Mapk14,Bcar1,Calm3,Crkl,Gnaq,Grb2,Hras,Prkcb,Map2k1,Map2k3,Map2k4,Sos1,Calm1,Jun,Pak1,Prkca,Map3k1,Mapk3,Mapk8,Plcg1,Map2k2,Raf1
FOUNDER_NAMES