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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Mm" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_PYK2_PATHWAY" SYSTEMATIC_NAME="MM1431" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/mouse/m_pyk2Pathway.gif" CHIP="MOUSE_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="Links between Pyk2 and Map Kinases" DESCRIPTION_FULL="This diagram is a compilation of Pyk2 effort cascades. In specific cell types the receptor and effoectors will vary. Binding of a transmembrane receptor triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and further to the small G protein Rac1. In turn, Rac1 initiatates the JNK cascade, starting with PAK follwed by MEKK1, SEK1, and JNK. JNK activation causes induction of c-Jun gene binding. Pyk2 stimulation has also been shown to activate MKK3 leading to activation of p38. The other major mitogen activated kinase cascade for ERK1/2 is stimulated via RAS, RAF and MEKK1/2." TAGS="" MEMBERS="AK136923,AK155158,BC023080,BG694441,BU515502,BY761703,GH455388,NM_001038663,NM_001162366,NM_001168513,NM_001198839,NM_007590,NM_007764,NM_008139,NM_008163,NM_008284,NM_008855,NM_008927,NM_008928,NM_009157,NM_009231,NM_009790,NM_010591,NM_011035,NM_011101,NM_011945,NM_011952,NM_016700,NM_021280,NM_023138,NM_029780" MEMBERS_SYMBOLIZED="Bcar1,Calm1,Calm3,Crkl,Gnaq,Grb2,Hras,Jun,Map2k1,Map2k2,Map2k3,Map2k4,Map3k1,Mapk1,Mapk14,Mapk3,Mapk8,Pak1,Plcg1,Prkca,Prkcb,Ptk2b,Raf1,Shc1,Sos1" MEMBERS_EZID="110157,12313,12315,12927,12929,14682,14784,15461,16476,18479,18750,18751,18803,19229,20416,20662,26395,26396,26397,26398,26401,26413,26416,26417,26419" MEMBERS_MAPPING="AK136923,null,null|AK155158,Shc1,20416|BC023080,Crkl,12929|BG694441,null,null|BU515502,null,null|BY761703,null,null|GH455388,null,null|NM_001038663,Mapk1,26413|NM_001162366,Ptk2b,19229|NM_001168513,Mapk14,26416|NM_001198839,Bcar1,12927|NM_007590,Calm3,12315|NM_007764,Crkl,12929|NM_008139,Gnaq,14682|NM_008163,Grb2,14784|NM_008284,Hras,15461|NM_008855,Prkcb,18751|NM_008927,Map2k1,26395|NM_008928,Map2k3,26397|NM_009157,Map2k4,26398|NM_009231,Sos1,20662|NM_009790,Calm1,12313|NM_010591,Jun,16476|NM_011035,Pak1,18479|NM_011101,Prkca,18750|NM_011945,Map3k1,26401|NM_011952,Mapk3,26417|NM_016700,Mapk8,26419|NM_021280,Plcg1,18803|NM_023138,Map2k2,26396|NM_029780,Raf1,110157" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="M2" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
