STANDARD_NAME	ELLWOOD_MYC_TARGETS_DN
SYSTEMATIC_NAME	MM814
COLLECTION	M2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/mouse/geneset/ELLWOOD_MYC_TARGETS_DN
NAMESPACE	AFFY_MG_U74
DESCRIPTION_BRIEF	Genes down-regulated in transgenic mice expressing human MYC [GeneID=4609] in prostate.
DESCRIPTION_FULL	Increased Myc gene copy number is observed in human prostate cancer. To define Myc's functional role, we generated transgenic mice expressing human c-Myc in the mouse prostate. All mice developed murine prostatic intraepithelial neoplasia followed by invasive adenocarcinoma. Microarray-based expression profiling identified a Myc prostate cancer expression signature, which included the putative human tumor suppressor NXK3.1. Human prostate tumor databases revealed modules of human genes that varied in concert with the Myc prostate cancer signature. This module includes the Pim-1 kinase, a gene known to cooperate with Myc in tumorigenesis, and defines a subset of human, Myc-like human cancers. This approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases.
PMID	14522256
GEOID	
AUTHORS	Ellwood-Yen K,Graeber TG,Wongvipat J,Iruela-Arispe ML,Zhang J,Matusik R,Thomas GV,Sawyers CL
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1S: rank <= 60, direction = down
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	100084_at,100633_at,101410_at,102774_at,102801_at,103047_at,103412_at,103686_at,103743_at,103974_at,104087_at,104627_at,160144_at,160240_at,160290_at,160376_at,92642_at,93389_at,93833_s_at,94207_at,94398_s_at,94454_at,94473_at,94982_f_at,95137_at,96058_s_at,96090_g_at,96608_at,96708_at,96773_at,96894_at,97157_at,97451_at,97516_at,97807_at,97841_at,98065_at,98849_at,98915_at,99076_at,99152_at,99164_at,99546_at,99665_at
GENE_SYMBOLS	Ezr,Mtarc2,Cldn4,Egf,Bglap3,Pex2,Limch1,Mcoln2,Limch1,Tmprss2,Anapc16,Cds2,Dnajc10,Smim14,Ide,Trp53inp2,Car2,Prom1,H2bc4,Pdia6,Inpp5b,Dazap2,Pttg1ip,Mrps34,Tmem97,Aldh2,4931406C07Rik,Phyh,Tmed3,Erp44,Tmed4,Nkx3-1,Mcfd2,Ganab,Ufc1,Chmp2a,Ormdl3,Tmem170,Rnf149,Nr1d2,Fmod,Lamtor2,Fkbp2,Satb1
FOUNDER_NAMES