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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Mm" NAME="export">
    <GENESET STANDARD_NAME="ELLWOOD_MYC_TARGETS_DN" SYSTEMATIC_NAME="MM814" HISTORICAL_NAMES="" PMID="14522256" AUTHORS="Ellwood-Yen K,Graeber TG,Wongvipat J,Iruela-Arispe ML,Zhang J,Matusik R,Thomas GV,Sawyers CL" GEOID="" EXACT_SOURCE="Table 1S: rank &lt;= 60, direction = down" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="AFFY_MG_U74" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes down-regulated in transgenic mice expressing human MYC [GeneID=4609] in prostate." DESCRIPTION_FULL="Increased Myc gene copy number is observed in human prostate cancer. To define Myc's functional role, we generated transgenic mice expressing human c-Myc in the mouse prostate. All mice developed murine prostatic intraepithelial neoplasia followed by invasive adenocarcinoma. Microarray-based expression profiling identified a Myc prostate cancer expression signature, which included the putative human tumor suppressor NXK3.1. Human prostate tumor databases revealed modules of human genes that varied in concert with the Myc prostate cancer signature. This module includes the Pim-1 kinase, a gene known to cooperate with Myc in tumorigenesis, and defines a subset of human, Myc-like human cancers. This approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases." TAGS="" MEMBERS="100084_at,100633_at,101410_at,102774_at,102801_at,103047_at,103412_at,103686_at,103743_at,103974_at,104087_at,104627_at,160144_at,160240_at,160290_at,160376_at,92642_at,93389_at,93833_s_at,94207_at,94398_s_at,94454_at,94473_at,94982_f_at,95137_at,96058_s_at,96090_g_at,96608_at,96708_at,96773_at,96894_at,97157_at,97451_at,97516_at,97807_at,97841_at,98065_at,98849_at,98915_at,99076_at,99152_at,99164_at,99546_at,99665_at" MEMBERS_SYMBOLIZED="4931406C07Rik,Aldh2,Anapc16,Bglap3,Car2,Cds2,Chmp2a,Cldn4,Dazap2,Dnajc10,Egf,Erp44,Ezr,Fkbp2,Fmod,Ganab,H2bc4,Ide,Inpp5b,Lamtor2,Limch1,Mcfd2,Mcoln2,Mrps34,Mtarc2,Nkx3-1,Nr1d2,Ormdl3,Pdia6,Pex2,Phyh,Prom1,Pttg1ip,Rnf149,Satb1,Smim14,Tmed3,Tmed4,Tmem170,Tmem97,Tmprss2,Trp53inp2,Ufc1" MEMBERS_EZID="103694,108705,110911,11669,12095,12349,12740,13645,14227,14264,14376,15925,16330,16922,18095,19126,19302,193813,20230,22350,23994,353187,50528,52717,66111,66155,66612,66817,66861,67247,67702,68024,68279,68552,68728,68953,69071,70984,71853,76299,77569,79044,83409" MEMBERS_MAPPING="100084_at,Ezr,22350|100633_at,Mtarc2,67247|101410_at,Cldn4,12740|102774_at,Egf,13645|102801_at,Bglap3,12095|103047_at,Pex2,19302|103412_at,Limch1,77569|103686_at,Mcoln2,68279|103743_at,Limch1,77569|103974_at,Tmprss2,50528|104087_at,Anapc16,52717|104627_at,Cds2,110911|160144_at,Dnajc10,66861|160240_at,Smim14,68552|160290_at,Ide,15925|160376_at,Trp53inp2,68728|92642_at,Car2,12349|93389_at,Prom1,19126|93833_s_at,H2bc4,68024|94207_at,Pdia6,71853|94398_s_at,Inpp5b,16330|94454_at,Dazap2,23994|94473_at,Pttg1ip,108705|94982_f_at,Mrps34,79044|95137_at,Tmem97,69071|96058_s_at,Aldh2,11669|96090_g_at,4931406C07Rik,70984|96608_at,Phyh,16922|96708_at,Tmed3,66111|96773_at,Erp44,76299|96894_at,Tmed4,103694|97157_at,Nkx3-1,18095|97451_at,Mcfd2,193813|97516_at,Ganab,14376|97807_at,Ufc1,66155|97841_at,Chmp2a,68953|98065_at,Ormdl3,66612|98849_at,Tmem170,66817|98915_at,Rnf149,67702|99076_at,Nr1d2,353187|99152_at,Fmod,14264|99164_at,Lamtor2,83409|99546_at,Fkbp2,14227|99665_at,Satb1,20230" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="M2" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
