STANDARD_NAME	FUKUSHIMA_TNFSF11_TARGETS
SYSTEMATIC_NAME	MM1296
COLLECTION	M2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/mouse/geneset/FUKUSHIMA_TNFSF11_TARGETS
NAMESPACE	Mouse_RefSeq
DESCRIPTION_BRIEF	Genes up-regulated in RAW 264.7 cells (macrophage) upon stimulation with TNFSF11 [GeneID=8600].
DESCRIPTION_FULL	Notch signaling plays a key role in various cell differentiation processes including bone homeostasis. However, the specific involvement of Notch in regulating osteoclastogenesis is still controversial. In the present study, we show that RANKL induces expression of Jagged1 and Notch2 in bone marrow macrophages during osteoclast differentiation. Suppression of Notch signaling by a selective gamma-secretase inhibitor or Notch2 short hairpin RNA suppresses RANKL-induced osteoclastogenesis. In contrast, induction of Notch signaling by Jagged1 or by ectopic expression of intracellular Notch2 enhances NFATc1 promoter activity and expression and promotes osteoclastogenesis. Finally, we found that Notch2 and p65 interact in the nuclei of RANKL-stimulated cells and that both proteins are recruited to the NFATc1 promoter, driving its expression. Taken together, our results show a new molecular cross talk between Notch and NF-kappaB pathways that is relevant in osteoclastogenesis.
PMID	18710934
GEOID	
AUTHORS	Fukushima H,Nakao A,Okamoto F,Shin M,Kajiya H,Sakano S,Bigas A,Jimi E,Okabe K
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	NM_007588,NM_007865,NM_007866,NM_008235,NM_008714,NM_008716,NM_009035,NM_010423,NM_010588,NM_010928,NM_010929,NM_011613,NM_013822,NM_016791,NM_019454,NM_021330
GENE_SYMBOLS	Calcr,Dll1,Dll3,Hes1,Notch1,Notch3,Rbpj,Hey1,Jag2,Notch2,Notch4,Tnfsf11,Jag1,Nfatc1,Dll4,Acp1
FOUNDER_NAMES