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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Mm" NAME="export">
    <GENESET STANDARD_NAME="ONO_AML1_TARGETS_UP" SYSTEMATIC_NAME="MM1268" HISTORICAL_NAMES="" PMID="17377532" AUTHORS="Ono M,Yaguchi H,Ohkura N,Kitabayashi I,Nagamura Y,Nomura T,Miyachi Y,Tsukada T,Sakaguchi S" GEOID="" EXACT_SOURCE="Fig. S7: AML1, red" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="MOUSE_GENE_SYMBOL" CONTRIBUTOR="Jessica Robertson" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes up-regulated in CD4+ [GeneID=920] T lymphocytes by expression of AML1 [GeneID=861] off a viral vector." DESCRIPTION_FULL="Naturally arising CD25+CD4+ regulatory T cells (T(R) cells) are engaged in the maintenance of immunological self-tolerance and immune homeostasis by suppressing aberrant or excessive immune responses, such as autoimmune disease and allergy. T(R) cells specifically express the transcription factor Foxp3, a key regulator of T(R)-cell development and function. Ectopic expression of Foxp3 in conventional T cells is indeed sufficient to confer suppressive activity, repress the production of cytokines such as interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), and upregulate T(R)-cell-associated molecules such as CD25, cytotoxic T-lymphocyte-associated antigen-4, and glucocorticoid-induced TNF-receptor-family-related protein. However, the method by which Foxp3 controls these molecular events has yet to be explained. Here we show that the transcription factor AML1 (acute myeloid leukaemia 1)/Runx1 (Runt-related transcription factor 1), which is crucially required for normal haematopoiesis including thymic T-cell development, activates IL-2 and IFN-gamma gene expression in conventional CD4+ T cells through binding to their respective promoters. In natural T(R) cells, Foxp3 interacts physically with AML1. Several lines of evidence support a model in which the interaction suppresses IL-2 and IFN-gamma production, upregulates T(R)-cell-associated molecules, and exerts suppressive activity. This transcriptional control of T(R)-cell function by an interaction between Foxp3 and AML1 can be exploited to control physiological and pathological T-cell-mediated immune responses." TAGS="" MEMBERS="Ccnf,Cd244,CD38,Cxcr6,Ddx5,Dlk1,E2f1,Eomes,Fasl,Fos,Gadd45b,Gpr105,Gzma,Gzmc,Havcr2,Ifng,Jun,Mecp2,Nkg7,Pak1,Pdcd1,Pdcd1lg2,Rgs2,Sema4a,Slamf7" MEMBERS_SYMBOLIZED="Ccnf,Cd244a,Cxcr6,Ddx5,Dlk1,E2f1,Eomes,Fasl,Fos,Gadd45b,Gzma,Gzmc,Havcr2,Ifng,Jun,Mecp2,Nkg7,P2ry14,Pak1,Pdcd1,Pdcd1lg2,Rgs2,Sema4a,Slamf7" MEMBERS_EZID="12449,13207,13386,13555,13813,140795,14103,14281,14938,14940,15978,16476,171285,17257,17873,18106,18479,18566,19735,20351,58205,72310,75345,80901" MEMBERS_MAPPING="CD38,null,null|Ccnf,Ccnf,12449|Cd244,Cd244a,18106|Cxcr6,Cxcr6,80901|Ddx5,Ddx5,13207|Dlk1,Dlk1,13386|E2f1,E2f1,13555|Eomes,Eomes,13813|Fasl,Fasl,14103|Fos,Fos,14281|Gadd45b,Gadd45b,17873|Gpr105,P2ry14,140795|Gzma,Gzma,14938|Gzmc,Gzmc,14940|Havcr2,Havcr2,171285|Ifng,Ifng,15978|Jun,Jun,16476|Mecp2,Mecp2,17257|Nkg7,Nkg7,72310|Pak1,Pak1,18479|Pdcd1,Pdcd1,18566|Pdcd1lg2,Pdcd1lg2,58205|Rgs2,Rgs2,19735|Sema4a,Sema4a,20351|Slamf7,Slamf7,75345" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="M2" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
